INBIRS   24491
INSTITUTO DE INVESTIGACIONES BIOMEDICAS EN RETROVIRUS Y SIDA
Unidad Ejecutora - UE
artículos
Título:
First hepatitis B virus full-length genomic study among blood donors from Argentina: unexpected mutations in the circulating subgenotypes? proteins.
Autor/es:
DELFINO C; BERINI C; PEDROZO W; MALAN R; BLEJER J; OUBIÑA JR; BIGLIONE MM; MATHET VL
Revista:
VIRUS GENES
Editorial:
SPRINGER
Referencias:
Lugar: Berlin; Año: 2014
ISSN:
0920-8569
Resumen:
Hepatitis B virus (HBV) is a worldwide public
health concern. The circulation of strains carrying mutations
in the viral proteins implies both clinical and therapeutics
challenges. HBV complete genomes (HBV-CGs)
were reported from injecting drug users and HBV chronically
infected patients from Argentina?including Amerindians?
although no studies were conducted in blood
donors. Here, we described HBV-CG sequences from the
latter population. Some of the HBV sequences classified as B2 and C2 subgenotypes clustering together with Asian
isolates, while others, such as D3, F1b, and F4, were
homologous to European and Latin America sequences.
New substitutions for all analyzed open reading frames and
changes in the HBsAg hydrophobicity profiles were
detected. Several HBV-CG subgenotypes are described for
the first time in this population. Mutations observed in X,
PreS, and P proteins have been associated with advanced
liver disease, hepatocellular carcinoma, and/or natural
resistance to nucleos(t)ide antiviral treatment. It deserves
to be highlighted that these substitutions were detected in a
population without epidemiological risk factors for viral
infection, and most importantly, without any previous
antiviral treatment (natural resistance). Regarding the
remaining mutations, further research is warranted in order
to determine their clinical and therapeutics relevance.