Thyrotropin-releasing hormone in cardiovascular pathophysiology.

GARCIA , SILVIA INES; PIROLA, CARLOS JOSE

REGULATORY PEPTIDES

Año: 2005 vol. 30 p. 239 - 246

0167-0115

Thyrotropin-releasing hormone in cardiovascular pathophysiology Silvia I. Garcý´a, Carlos J. PirolaTCardiologý´a Molecular, Instituto de Investigaciones Me´dicas A Lanari, Universidad de Buenos Aires and CONICET, Combatientes de Malvinas 3150 1427-Buenos Aires, Argentina Available online 23 February 2005 Abstract Thyrotropin (TSH)-releasing hormone (TRH) also known as thyroliberin was the first of a number of peptides exerting several roles as a hormone and as a neuropeptide. Its ubiquitous distribution in the hypothalamus and in the extrahypothalamic regions and its diverse pharmacological and physiological effects are all features of its dual functions. For this reason, TRH has been the subject of much research throughout the past 20 years, work that has examined the structure, function, distribution, and regulation of the tripeptide and it has been extensively reviewed elsewhere [1,2] [O’Leary R., O’Connor B. Thyrotropin-releasing hormone. J Neurochem. 1995;65:953–963.; Nillni E., Sevarino K. The biology of pro-thyrotropin-releasing hormone-derived peptides. Endocrine Reviews, 1999;20:599–664.]. After a brief overview of its distribution, hypothalamic and extrahypothalamic functions, and receptors involved, this review discusses efforts devoted to support TRH role in cardiovascular regulation with a main focus on hypertension pathophysiology in experimental models and humans. D 2005 Elsevier B.V. All rights reserved. Keywords: TRH; Thyroliberin; Antisense; iRNA; Blood pressure; Hypertension; Obesity; Leptin Peptides 128 (2005) 239–246 TCardiologý´a Molecular, Instituto de Investigaciones Me´dicas A Lanari, Universidad de Buenos Aires and CONICET, Combatientes de Malvinas 3150 1427-Buenos Aires, Argentina Available online 23 February 2005 Abstract Thyrotropin (TSH)-releasing hormone (TRH) also known as thyroliberin was the first of a number of peptides exerting several roles as a hormone and as a neuropeptide. Its ubiquitous distribution in the hypothalamus and in the extrahypothalamic regions and its diverse pharmacological and physiological effects are all features of its dual functions. For this reason, TRH has been the subject of much research throughout the past 20 years, work that has examined the structure, function, distribution, and regulation of the tripeptide and it has been extensively reviewed elsewhere [1,2] [O’Leary R., O’Connor B. Thyrotropin-releasing hormone. J Neurochem. 1995;65:953–963.; Nillni E., Sevarino K. The biology of pro-thyrotropin-releasing hormone-derived peptides. Endocrine Reviews, 1999;20:599–664.]. After a brief overview of its distribution, hypothalamic and extrahypothalamic functions, and receptors involved, this review discusses efforts devoted to support TRH role in cardiovascular regulation with a main focus on hypertension pathophysiology in experimental models and humans. D 2005 Elsevier B.V. All rights reserved. Keywords: TRH; Thyroliberin; Antisense; iRNA; Blood pressure; Hypertension; Obesity; Leptin Peptides 128 (2005) 239–246