INBA   12521
INSTITUTO DE INVESTIGACIONES EN BIOCIENCIAS AGRICOLAS Y AMBIENTALES
Unidad Ejecutora - UE
artículos
Título:
Cyclin D1 is a NF-kappaB corepressor
Autor/es:
RUBIO F; FERNANDEZ-LARROSA P; ALVARADO C; PANELO LC; GRECCO M; COLO GP; MARTÍNEZ NOËL G; MICENMACHER S; COSTAS M
Revista:
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Año: 2012 vol. 1823 p. 1119 - 1131
ISSN:
0167-4889
Resumen:
NF-kappaB regulates the expression of Cyclin D1 (CD1), while RAC3 is an NF-kappaB coactivator that enhances its transcriptional activity. In this work, we investigated the regulatory role of CD1 on NF-kappaB activity. We found that CD1 inhibits NF-kappaB transcriptional activity through a corepressor function that can be reverted by over-expressing RAC3. In both, tumoral and non-tumoral cells, the expression pattern of RAC3 and CD1 is regulated by the cell cycle, showing a gap between the maximal expression levels of each protein. The individual increase, by transfection, of either CD1 or RAC3 enhances cell proliferation. However the simultaneous and constitutive over-expression of both proteins has an inhibitory effect. Our results suggest that the relative amounts of CD1 and RAC3, and the timing of expression of these oncogenes could tilt the balance of tumor cell proliferation in response to external signals.