Structural and molecular mechanisms related to α-Synuclein formation and its inhibition

NAZARENO GONZÁLEZ; GARRO, HUGO A.; FERNÁNDEZ, CLAUDIO O.

Congreso; Synuclein Meeting 2019; 2019

The interaction of α‐synuclein with physiologically relevant metal ions, highlighting the cases where metal‐α‐synuclein interactions profile are key modulators of α‐synuclein structural, aggregation, and membrane‐binding properties. The impact of α‐synuclein phosphorylation, sumoylation, and N‐terminal acetylation in the metal‐binding properties of the protein are also discussed, underscoring a potential interplay between post‐translational modifications and metal ion binding in regulating α‐synuclein physiological functions and its role in pathology.