INVESTIGADORES
SALINAS Maria Victoria
artículos
Título:
Antioxidant effects of the VO(IV) Hesperidin complex and its role in cancer chemoprevention
Autor/es:
S.B. ETCHEVERRY; E. G. FERRER; L. NASO; J. RIVADANEIRA; M.V. SALINAS; P.A.M. WILLIAMS
Revista:
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
Editorial:
Springer
Referencias:
Lugar: Berlin, Alemania; Año: 2008 vol. 13 p. 435 - 447
ISSN:
0949-8257
Resumen:
Vanadium compounds are known for a variety
of pharmacological properties. Many of them display
antitumoral and osteogenic effects in several cell lines.
Free radicals induce the development of tumoral processes.
Natural polyphenols such as flavonoids have antioxidant
properties since they scavenge different free radicals. For
these reasons it is interesting to investigate the effects of a
new complex generated between the vanadyl(IV) cation
and the flavonoid hesperidin. The complex has been synthesized
and characterized by physicochemical methods.
Spectroscopic analysis revealed a 1:1 stoichiometry of
ligand:VO and coordination by deprotonated cis-hydroxyl
groups to the disaccharide moiety of the ligand. The
complex improves the superoxide dismutase (SOD)-like
activity of the ligand, but the scavenging of other radicals
tested does not change upon complexation. When tested on
two tumoral cell lines in culture (one of them derived from
a rat osteosarcoma UMR106 and the other from human
colon adenocarcinoma Caco-2), the complex enhanced the
antiproliferative effects of the free ligand, and this effect
correlated with the morphological alterations toward
apoptosis. Also, on the osteoblastic cell line the complex
stimulated cell proliferation and collagen type I production
at low concentrations. At higher doses the complex behaved
as a cytotoxic compound for the osteoblasts.