ENCAPSULATION OF ESSENTIAL OIL OBTAINED FROM SCHINUS AREIRA FROM SANTIAGO DEL ESTERO. CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY AGAINST S. AUREUS

CUTRO, ANDREA C.; HOLLMANN, AXEL; RODRÍGUEZ, S. A.

Congreso; LVII SAIB Meeting - XVI SAMIGE Meeting; 2021

ENCAPSULATION OF ESSENTIAL OIL OBTAINED FROM SCHINUS AREIRA FROM SANTIAGO DEL ESTERO. CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY AGAINST S. AUREUSCutro AC , Hollmann A, Rodriguez SA1 Laboratorio Compuestos Bioactivos, CIBAAL (UNSE-CONICET); 2 Facultad de Ciencias Médicas (FCM UNSE) 3 Facultad de Agronomía y Agroindustrias (FAyA UNSE), CONICET E-mail: cutro.andrea@gmail.comEssential oil (EO) extracted by hydrodistillation from specimens of the species Schinus areira (Aguaribay) has been used in traditional medicine. Previously, we reported that EO obtained from S. areira leaves from Santiago del Estero (SDE) showed antibacterial action against Staphylococcus aureus. New studies were carried out with EO obtained in a second period, after its chemical characterization, the biological activity and liposomal encapsulation were assayed. The liposomes with EO encapsulated were obtained by the hydration of mixed lipid film generated from dipalmitoyl phosphatidylcholine (DPPC) and EO with a mass ratio of 1: 1, obtaining DPPC:EO multilamellar liposomes (MLV). Then they were characterized by physicochemical and microbiological methods. Size distribution and Zeta potential were determined by using dynamic light scattering (DLS Horiba, Nanosizer), DPPC MLVs were used as control. Formulations of MLVs with EO showed a significantly smaller size (p