BIOPHYSICAL AND ANTIBACTERIAL STUDIES OF ESSENTIAL OIL FROM LEAVES OF SCHINUS

CUTRÓ A. C.; CASTELLI M. V.; ROSALES M.; LÓPEZ S. N.; HOLLMANN A.; RODRIGUEZ SERGIO A.; RODRÍGUEZ, S. A.

Salta

Congreso; Joint LV Annual SAIB Meeting and XIV PABMB Congress; 2019

The genus Schinus (Anacardiaceae) is a native species from the north-west region of Argentina, which different traditional uses in medicinehave been reported. However, only a few studies have been conducted screening the antimicrobial properties of Schinus areira essential oil(E.O.). In this context, S.areira E.O. isolated from leaves of plants located in Santiago del Estero was obtained by hydrodistillation; and itschemical composition and antibacterial action were determined. Bioautography assays have shown that S. areira E.O. presents antibacterialactivity on Staphylococcus aureus but no effect was observed in Escherichia coli. The minimal inhibitory concentration and minimalbactericidal concentration were determined for S. aureus and the values obtained were 64 μg/mL and 256 μg/mL, respectively. In order to betterdescribe the effect of S. areira ermined at differentwas related to aDMPG(5:1) liposomes that mimic bacterialmembranes, was observed after the addition of increasing E.O. concentrations. These results could indicate a direct and differential interaction ofcertain chemical components of S. areira E.O. with bacterial surface and membrane. Besides, further studies should be carried out. The fact thatthe E.O. exhibited a high antibacterial effect against S. aureus represents an important milestone for the future development of antimicrobialcompounds.