DOMINGUEZ, LUCIANA M.; BUELONI, BARBARA; CANTERO, MARIA JOSE; ALBORNOZ, MILAGROS; PACIENZA, NATALIA; BIANI, CELESTE; LUZZANI, CARLOS; MIRIUKA, SANTIAGO; GARCIA, MARINA; ATORRASAGASTI, CATALINA; YANNARELLI, GUSTAVO; BAYO, JUAN; FIORE, ESTEBAN; MAZZOLINI, GUILLERMO D.

Chromatographic Scalable Method to Isolate Engineered Extracellular Vesicles Derived from Mesenchymal Stem Cells for the Treatment of Liver Fibrosis in Mice

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; Lugar: Basel; Año: 2023

AMIN, GUADALUPE; CASTAÑEDA, SHEILA; ZABALEGUI, FEDERICO; BELLI, CAROLINA; ATORRASAGASTI, CATALINA; MIRIUKA, SANTIAGO; MORO, LUCÍA

Generation of two edited iPSCs lines by CRISPR/Cas9 with point mutations in PKP2 gene for arrhythmogenic cardiomyopathy in vitro modeling

Stem Cell Research; Año: 2023 vol. 71

ONORATO, AGOSTINA; LAMEROLI, LUCÍA; BAYO, JUAN; FIORE, ESTEBAN; CANTERO, MARIA JOSE; BUELONI, BARBARA; GARCIA, MARIANA; LAGUES, CECILIA; MARTINEZ DUARTEZ, PEDRO; MENALDI, GABRIEL; PALEARI, NICOLAS; ATORRASAGASTI, CATALINA; MAZZOLINI, GUILLERMO D.

Hepatic SPARC Expression Is Associated with Inflammasome Activation during the Progression of Non-Alcoholic Fatty Liver Disease in Both Mice and Morbidly Obese Patients

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; Año: 2023 vol. 24

ATORRASAGASTI C; ONORATO A; MAZZOLINI G

The role of SPARC (secreted protein acidic and rich in cysteine) in the pathogenesis of obesity, type 2 diabetes, and non‑alcoholic fatty liver disease

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY; Año: 2022

M. ONORATO, AGOSTINA; FIORE, ESTEBAN; BAYO, JUAN; CASALI, CECILIA; FERNANDEZ-TOMÉ, MARÍA; RODRÍGUEZ, MARCELO; DOMÍNGUEZ, LUCIANA; ARGEMI, JOSEPMARÍA; HIDALGO, FLORENCIA; FAVRE, CRISTIAN; GARCÍA, MARIANA; ATORRASAGASTI, CATALINA*; MAZZOLINI, GUILLERMO D.* (*IGUAL CONTRIBUCIÓN)

SPARC inhibition accelerates NAFLD-associated hepatocellular carcinoma development by dysregulating hepatic lipid metabolism

LIVER INTERNATIONAL; Año: 2021 vol. 41 p. 1677 - 1693

ATORRASAGASTI, CATALINA; PICCIONI, FLAVIA; BOROWSKI, SOPHIA; TIRADO-GONZÁLEZ, IRENE; FREITAG, NANCY; CANTERO, MARÍA JOSÉ; BAYO, JUAN; MAZZOLINI, GUILLERMO; ALANIZ, LAURA D.; BLOIS, SANDRA M.; GARCIA, MARIANA G.

Acceleration of taa-induced liver fibrosis by stress exposure is associated with upregulation of nerve growth factor and glycopattern deviations

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; Lugar: Basel; Año: 2021 vol. 22

RODRÍGUEZ, MARCELO M.; ONORATO, AGOSTINA; CANTERO, MARÍA JOSÉ; DOMÍNGUEZ, LUCIANA; BAYO, JUAN; FIORE, ESTEBAN; GARCÍA, MARIANA; ATORRASAGASTI, CATALINA; CANBAY, ALI; MALVICINI, MARIANA; MAZZOLINI, GUILLERMO D.

4-methylumbelliferone-mediated polarization of M1 macrophages correlate with decreased hepatocellular carcinoma aggressiveness in mice

Scientific Reports; Lugar: Londres; Año: 2021 vol. 11

ATORRASAGASTI, CATALINA; PICCIONI, FLAVIA; BOROWSKI, SOPHIA; TIRADO-GONZÁLEZ, IRENE; FREITAG, NANCY; CANTERO, MARÍA JOSÉ; BAYO, JUAN; MAZZOLINI, GUILLERMO; ALANIZ, LAURA D.; BLOIS, SANDRA M.; GARCIA, MARIANA G.

Acceleration of taa-induced liver fibrosis by stress exposure is associated with upregulation of nerve growth factor and glycopattern deviations

International Journal of Molecular Sciences; Lugar: Basel; Año: 2021 vol. 22

MAZZOLINI, GUILLERMO; SOWA, JAN-PETER; ATORRASAGASTI, CATALINA; KÜCÜKOGLU, ÖZLEM; SYN, WING-KIN; CANBAY, ALI

Significance of Simple Steatosis: An Update on the Clinical and Molecular Evidence

Cells; Año: 2020 vol. 9

FIORE, ESTEBAN; DOMÍNGUEZ, LUCIANA M.; BAYO, JUAN; MALVICINI, MARIANA; ATORRASAGASTI, CATALINA; RODRIGUEZ, MARCELO; CANTERO, MARÍA JOSÉ; GARCÍA, MARIANA; YANNARELLI, GUSTAVO; MAZZOLINI, GUILLERMO

Human umbilical cord perivascular cells-derived extracellular vesicles mediate the transfer of IGF-I to the liver and ameliorate hepatic fibrogenesis in mice

GENE THERAPY; Año: 2020 vol. 27 p. 62 - 73

JUAN BAYO; ESTEBAN FIORE; DOMINGUEZ, LUCIANA M.; CANTERO, MARIA JOSE; CIARLANTINI, MATIAS; MALVICINI, MARIANA; ATORRASAGASTI, CATALINA; GARCIA, MARIANA; ROSSI, MARIO; CAVASOTTO, CLAUDIO; MARTINEZ, ELISABETH D.; COMIN, JULIETA; MAZZOLINI, GUILLERMO

Bioinformatic analysis of RHO family of GTPases identifies RAC1 pharmacological inhibition as a new therapeutic strategy for hepatocellular carcinoma

GUT - AN INTERNATIONAL JOURNAL OF GASTROENTEOROLOGY AND HEPATOLOGY; Lugar: Londres; Año: 2020

FIORE, ESTEBAN; DOMÍNGUEZ, LUCIANA M.; BAYO, JUAN; MALVICINI, MARIANA; ATORRASAGASTI, CATALINA; RODRIGUEZ, MARCELO; CANTERO, MARÍA JOSÉ; GARCÍA, MARIANA; YANNARELLI, GUSTAVO; MAZZOLINI, GUILLERMO

Human umbilical cord perivascular cells-derived extracellular vesicles mediate the transfer of IGF-I to the liver and ameliorate hepatic fibrogenesis in mice

GENE THERAPY; Año: 2019 vol. 27 p. 62 - 73

FIORE, ESTEBAN; DOMÍNGUEZ, LUCIANA M.; BAYO, JUAN; MALVICINI, MARIANA; ATORRASAGASTI, CATALINA; RODRIGUEZ, MARCELO; CANTERO, MARÍA JOSÉ; GARCÍA, MARIANA; YANNARELLI, GUSTAVO; MAZZOLINI, GUILLERMO

Human umbilical cord perivascular cells-derived extracellular vesicles mediate the transfer of IGF-I to the liver and ameliorate hepatic fibrogenesis in mice

GENE THERAPY; Año: 2019 vol. 27 p. 62 - 73

BAYO, JUAN; FIORE, ESTEBAN J.; DOMINGUEZ, LUCIANA M.; REAL, ALEJANDRINA; MALVICINI, MARIANA; RIZZO, MANGLIO; ATORRASAGASTI, CATALINA; GARCÍA, MARIANA G.; ARGEMI, JOSEPMARIA; MARTINEZ, ELISABETH D.; MAZZOLINI, GUILLERMO D.

A comprehensive study of epigenetic alterations in hepatocellular carcinoma identifies potential therapeutic targets

JOURNAL OF HEPATOLOGY; Lugar: Amsterdam; Año: 2019

ATORRASAGASTI, CATALINA; ONORATO, AGOSTINA; GIMENO, MARÍA L.; ANDREONE, LUZ; GARCIA, MARIANA; MALVICINI, MARIANA; FIORE, ESTEBAN; BAYO, JUAN; PERONE, MARCELO J.; MAZZOLINI, GUILLERMO D.

SPARC is required for the maintenance of glucose homeostasis and insulin secretion in mice

CLINICAL SCIENCE (LONDON, ENGLAND : 1979); Año: 2019 vol. 133 p. 351 - 365

RODRÍGUEZ, MARCELO M.; FIORE, ESTEBAN; BAYO, JUAN; ATORRASAGASTI, CATALINA; GARCÍA, MARIANA; ONORATO, AGOSTINA; DOMÍNGUEZ, LUCIANA; MALVICINI, MARIANA; MAZZOLINI, GUILLERMO

4Mu Decreases CD47 Expression on Hepatic Cancer Stem Cells and Primes a Potent Antitumor T Cell Response Induced by Interleukin-12

MOLECULAR THERAPY (PRINT); Año: 2018 vol. 26 p. 2738 - 2750

MAZZOLINI*, GUILLERMO * IGUAL CONTRIBUCIÓN; ATORRASAGASTI*, CATALINA *IGUAL CONTRIBUCION; ONORATO, AGOSTINA; PEIXOTO, ESTANISLAO; SCHLATTJAN, MARTIN; SOWA, JAN-PETER; SYDOR, SVENJA; GERKEN, GUIDO; CANBAY, ALI

SPARC expression is associated with hepatic injury in rodents and humans with non-alcoholic fatty liver disease

Scientific Reports; Lugar: Londres ; Año: 2018 vol. 8

FIORE E; MALVICINI M; BAYO J; ATORRASAGASTI C; SIERRA R; RODRIGUEZ M; GOMEZ-BUSTILLO S; GARCIA MG; AQUINO JB; MAZZOLINI G

Involvement of hepatic macrophages in the antifibrotic effect of IGF-I-overexpressing mesenchymal stromal cells

Stem cell research & therapy; Lugar: Londres; Año: 2016 vol. 7

PEIXOTO E; ATORRASAGASTI C; MALVICINI M; FIORE E; RODRIGUEZ M; GARCIA M; FINOCCHIETO P; PODEROSO JJ; CORRALES F; MAZZOLINI G

SPARC gene deletion protects against toxic liver injury and is associated to an enhanced proliferative capacity and reduced oxidative stress response.

Oncotarget; Lugar: New York; Año: 2016

MALVICINI M; FIORE E; GHIACCIO V; PICCIONI F; RIZZO MM; OLMEDO BONADEO L; GARCIA MG; RODRIGUEZ M; BAYO J; PEIXOTO E; ATORRASAGASTI C; ALANIZ L; AQUINO JB; MATAR P; MAZZOLINI G

Tumor Microenvironment Remodeling by 4-Methylumbelliferone Boosts the Antitumor Effect of Combined Immunotherapy in Murine Colorectal Carcinoma

MOLECULAR THERAPY (PRINT); Lugar: Londres; Año: 2015 vol. 23 p. 1444 - 1455

PICCIONI F; FIORE E; BAYO J; ATORRASAGASTI C; PEIXOTO E; RIZZO MM; MALVICINI M; TIRADO-GONZALEZ I; GARCIA MG; ALANIZ L; MAZZOLINI G

4-methylumbelliferone inhibits hepatocellular carcinoma growth by decreasing IL-6 production and angiogenesis

GLYCOBIOLOGY; Lugar: Oxford; Año: 2015 vol. 25 p. 825 - 835

FIORE E; BAYO J; GARCIA MG; MALVICINI M; LLOYD R; PICCIONI F; RIZZO MM; PEIXOTO E; SOLA MB; ATORRASAGASTI C; ALANIZ L; CAMILLETTI MA; ENGUITA M; PRIETO J; AQUINO JB; MAZZOLINI G

Mesenchymal stromal cells engineered to produce IGF-I by recombinant adenovirus ameliorate liver fibrosis in mice

STEM CELLS AND DEVELOPMENT; Lugar: New York; Año: 2015 vol. 24 p. 791 - 801

PEIXOTO* E *IGUAL CONTRIBUCION; ATORRASAGASTI* C *IGUAL CONTRIBUCION; AQUINO JB; MILITELLO R ; BAYO J; FIORE E; PICCIONI F; SALVATIERRA E; ALANIZ L; GARCIA MG; BATALLER R; CORRALES F; GIDEKEL M; PODHAJCER O; COLOMBO MI; MAZZOLINI G

SPARC (secreted protein acidic and rich in cysteine) knockdown protects mice from acute liver injury by reducing vascular endothelial cell damage

GENE THERAPY; Lugar: Londres; Año: 2015 vol. 22 p. 9 - 19

ATORRASAGASTI, CATALINA; ESTANISLAO PEIXOTO; AQUINO JB; NESTOR KIPPES; MARIANA MALVICINI; LAURA ALANIZ; MARIANA GARCIA; FLAVIA PICCIONI; ESTEBAN FIORE; JUAN BAYO; RAMON BATALLER; FERNANDO CORRALES; OSVALDO. L. PODHAJCER; GUILLERMO MAZZOLINI

Lack of the matricellular protein SPARC (secreted protein, acidic and rich in cysteine) attenuates liver fibrogenesis in mice.

PLOS ONE; Lugar: San Francisco; Año: 2013 p. 1 - 17

MALVICINI M; PICCIONI F; BAYO J; FIORE E; ATORRASAGASTI C; ALANIZ L; GARCIA M; AQUINO JB; GIDEKEL M; MATAR P; MAZZOLINI G

A successful combination of gene therapy and cyclophosphamide

Oncoimmunology; Lugar: Austin, TX; Año: 2012

MALVICINI M; ALANIZ L; BAYO J; GARCIA M; PICCIONI F; FIORE E; ATORRASAGASTI C; AQUINO JB; MATAR P; MAZZOLINI G

Single low-dose cyclophosphamide combined with interleukin-12 gene therapy is superior to a metronomic schedule in inducing immunity against colorectal carcinoma in mice

oncoimmunology; Lugar: Austin, TX; Año: 2012

ALANIZ L; MIGUEL RIZZO; GARCIA M; PICCIONI F; AQUINO JB; MALVICINI M; ATORRASAGASTI C; BAYO J; ETCHEVERRIA I; SAROBE P; MAZZOLINI G

Low molecular weight hyaluronan preconditioning of tumor-pulsed dendritic cells increases their migratory ability and induces immunity against murine colorectal carcinoma

CANCER IMMUNOLOGY IMMUNOTHERAPY; Año: 2011 p. 1383 - 1395

PICCIONI F; MALVICINI M; GARCIA MG; RODRIGUEZ M; ATORRASAGASTI C; KIPPES N; BUENA IT; RIZZO MM; BAYO J; AQUINO JB; VIOLA M; PASSI A; ALANIZ L; MAZZOLINI G

Antitumor effects of hyaluronic acid inhibitor 4-Methylumbelliferone in an orthotopic hepatocellular carcinoma model in mice

GLYCOBIOLOGY; Año: 2011

MALVICINI M; INGOLOTTI M; PICCIONI F; GARCIA M; BAYO J; ATORRASAGASTI C; ALANIZ L; AQUINO JB; ESPINOZA J; GIDEKEL M; GRACIELA SCHAROVSKY; MATAR P; MAZZOLINI G

Reversal of gastrointestinal carcinoma-induced immunosuppression and induction of antitumoural immunity by a combination of cyclophosphamide and gene transfer of IL-12

MOLECULAR ONCOLOGY; Año: 2011 p. 242 - 255

ATORRASAGASTI, CATALINA; AQUINO JB; HOFMAN L; ALANIZ L; MALVICINI M; MARIANA GARCIA; BENEDETTI L; FRIEDMAN SL; PODHAJCER OL; MAZZOLINI GD

SPARC down-regulation attenuates the profibrogenic response of hepatic stellate cells induced by TGF-β1 and PDGF.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY; Año: 2011 p. 739 - 748

CATALINA ATORRASAGASTI; MARIANA MALVICINI; JORGE B. AQUINO; LAURA ALANIZ; MARIANA GARCIA; MARCELA BOLONTRADE; MIGUEL RIZZO; OSVALDO. L. PODHAJCER; GUILLERMO MAZZOLINI

Overexpression of SPARC obliterates the in vivo tumorigenicity of human hepatocellular carcinoma cells

INTERNATIONAL JOURNAL OF CANCER. JOURNAL INTERNATIONAL DU CANCER.; Año: 2010 p. 2726 - 2740

MARIANA MALVICINI; MIGUEL RIZZO; LAURA ALANIZ; FEDERICO PIÑERO; MARIANA GARCIA; CATALINA ATORRASAGASTI; JORGE B. AQUINO; VIVIANA ROZADOS; GRACIELA SCHAROVSKY; PABLO MATAR; GUILLERMO MAZZOLINI

A Novel Synergistic Combination of Cyclophosphamide and Gene Transfer of Interleukin-12 Eradicates Colorectal Carcinoma in Mice

CLINICAL CANCER RESEARCH; Año: 2009 p. 7256 - 7265

PABLO MATAR; LAURA ALANIZ; VIVIANA ROZADOS; JORGE B. AQUINO; MARIANA MALVICINI; CATALINA ATORRASAGASTI; MANUEL GIDEKEL; MARCELO SILVA; GRACIELA SCHAROVSKY; GUILLERMO MAZZOLINI

Immunotherapy for liver tumors: present status and future prospects

JOURNAL OF BIOMEDICAL SCIENCE; Año: 2009 p. 16 - 30

LAURA ALANIZ; MIGUEL RIZZO; MARIANA MALVICINI; JORGE JAUNARENA; DIEGO AVELLA; CATALINA ATORRASAGASTI; JORGE B. AQUINO; MARIANA GARCIA; PABLO MATAR; MARCELO SILVA; GUILLERMO MAZZOLINI

Low molecular weight hyaluronan inhibits colorectal carcinoma growth by decreasing tumor cell proliferation and stimulating immune response

CANCER LETTERS; Lugar: Cancer Lett. 2009 Jun 8;278(1):9-16. Epub 2009 Jan 29; Año: 2009 p. 9 - 16

ALEJANDRA M. CAMINO; CATALINA ATORRASAGASTI; DANIELA MACCIO; FEDERICO PRADA; EDGARDO SALVATIERRA; MIGUEL RIZZO; LAURA ALANIZ; JORGE B. AQUINO; OSVALDO. L. PODHAJCER; MARCELO SILVA; GUILLERMO MAZZOLINI

Adenovirus-mediated inhibition of SPARC attenuates liver fibrosis in rats

JOURNAL OF GENE MEDICINE; Año: 2008 p. 993 - 1004

GUILLERMO MAZZOLINI; OIHANA MURILLO; CATALINA ATORRASAGASTI; JUAN DUBROT; IÑIGO TIRAPU; MIGUEL RIZZO; AINHOA ARINA; CARLOS ALFARO; ARANTZA AZPILICUETA; CARMEN BERASAIN; JOSÉ L PEREZ-GRACIA; ALVARO GONZALEZ; IGNACIO MELERO

Immunotherapy and immunoescape in colorectal cancer

WORLD JOURNAL OF GASTROENTEROLOGY; Año: 2007 vol. 13 p. 5822 - 5831

CARO, FLORENCIA; BERCOVICH, NATALIA; ATORRASAGASTI, CATALINA; LEVIN, MARIANO J; VAZQUEZ, MARTIN

Trypanosoma cruzi: analysis of the complete PUF RNA-binding protein family

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS; Año: 2006 p. 112 - 124

CARO, FLORENCIA; BERCOVICH, NATALIA; ATORRASAGASTI, CATALINA; VAZQUEZ, MARTIN; LEVIN, MARIANO J

Protein interactions within the TcZFP zinc finger family members of Trypanosoma cruzi: Implications for their functions

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS; Año: 2005 vol. 333 p. 1017 - 1025

VAZQUEZ, MARTIN; ATORRASAGASTI, CATALINA; BERCOVICH, NATALIA; VOLCOVICH, ROMINA; LEVIN, MARIANO J

Unique features of the Trypanosoma Cruzi U2AF35 splicing factor

MOLECULAR AND BIOCHEMICAL PARASITOLOGY; Año: 2003 vol. 128 p. 77 - 81