ESPERANTE, S.A.; ALVAREZ-PAGGI, D.; SALGUEIRO, M.; DESIMONE, M.F.; DE OLIVEIRA, G.A.P.; ARÁN, M.; GARCÍA-PARDO, J.; APTEKMANN, A.A.; VENTURA, S.; ALONSO, L.G.; DE PRAT-GAY, G.

A finely tuned interplay between calcium binding, ionic strength and pH modulates conformational and oligomerization equilibria in the Respiratory Syncytial Virus Matrix (M) protein

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS; Año: 2022 vol. 731

BORKOSKY, SILVIA S.; FASSOLARI, M; CAMPOS-LEON, KAREN; ROSSI, ANDRES HUGO; SALGUEIRO, MARIANO; PASCUALE, CARLA; PERALTA-MARTINEZ, RAMON; GASTON, K.; DE PRAT GAY, GONZALO

Biomolecular Condensation of the Human Papillomavirus E2 Master Regulator with p53: Implications in Viral Replication

JOURNAL OF MOLECULAR BIOLOGY; Lugar: Amsterdam; Año: 2022

GONZÁLEZ-FOUTEL, NICOLÁS S.; GLAVINA, JULIANA; BORCHERDS, WADE M.; SAFRANCHIK, MATÍAS; BARRERA-VILARMAU, SUSANA; SAGAR, AMIN; ESTAÑA, ALEJANDRO; BAROZET, AMELIE; GARRONE, NICOLÁS A.; FERNANDEZ-BALLESTER, GREGORIO; BLANES-MIRA, CLARA; SÁNCHEZ, IGNACIO E.; DE PRAT-GAY, GONZALO; CORTÉS, JUAN; BERNADÓ, PAU; PAPPU, ROHIT V.; HOLEHOUSE, ALEX S.; DAUGHDRILL, GARY W.; CHEMES, LUCÍA B.

Conformational buffering underlies functional selection in intrinsically disordered protein regions

Nature Structural and Molecular Biology; Año: 2022 vol. 29 p. 781 - 790

LOPEZ, NORA; CAMPOREALE, GABRIELA; SALGUEIRO, MARIANO; BORKOSKY, SILVIA S.; VISENTIN, ARACELI; P{ERALTA-MARTINEZ, RAMON; LOUREIRO, MARIA EUGENIA; DE PRAT GAY, GONZALO

Deconstructing virus condensates

PLOS PATHOGENS; Lugar: San Francisco; Año: 2021 vol. 17

LEROY, LUDMILA; BARBOSA, JOÃO ALEXANDRE RIBEIRO GONÇALVES; DE PRAT-GAY, GONZALO; POLIKARPOV, IGOR; PINHEIRO, CARLOS BASÍLIO

The structure of the extended E2 DNA-binding domain of the bovine papillomavirus-1

PROTEINS: STRUCTURE, FUNCTION AND GENETICS; Año: 2020 vol. 88 p. 106 - 112

ALVAREZ PAGGI, D.; ESPERANTE, S.A.; SALGUEIRO, M.; CAMPOREALE, G.; OLIVEIRA, G.A.; PRAT GAY, G.

A conformational switch balances viral RNA accessibility and protection in a nucleocapsid ring model

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS; Año: 2019

ALVAREZ-PAGGI, DAMIÁN; LORENZO, JUAN RAMIRO; CAMPOREALE, GABRIELA; MONTERO, LUCIANO; SÁNCHEZ, IGNACIO E; DE PRAT GAY, GONZALO; ALONSO, LEONARDO G

Topology Dictates Evolution of Regulatory Cysteines in a Family of Viral Oncoproteins

MOLECULAR BIOLOGY AND EVOLUTION; Lugar: Oxford; Año: 2019

CONCI, JULIETA; ALVAREZ-PAGGI, DAMIAN; DE OLIVEIRA, GUILHERME A. P.; PAGANI, TALITA D.; ESPERANTE, SEBASTIAN A.; BORKOSKY, SILVINA S.; ARAN, MARTIN; ALONSO, LEONARDO G.; MOHANA-BORGES, RONALDO; PRAT-GAY, GONZALO DE

Conformational Isomerization Involving Conserved Proline Residues Modulates Oligomerization of the NS1 Interferon Response Inhibitor from the Syncytial Respiratory Virus

BIOCHEMISTRY; Año: 2019

MOLINA, IVANA G.; JOSTS, INOKENTIJS; ALMEIDA HERNANDEZ, YASSER; ESPERANTE, SEBASTIAN; SALGUEIRO, MARIANO; GARCIA ALAI, MARIA M.; DE PRAT-GAY, GONZALO; TIDOW, HENNING

Structure and stability of the Human respiratory syncytial virus M2-1 RNA-binding core domain reveals a compact and cooperative folding unit

Acta Crystallographica Section F: Structural Biology Communications; Año: 2018 vol. 74 p. 23 - 30

MOLINA, IVANA G.; ESPERANTE, SEBASTIAN A.; MARINO-BUSLJE, CRISTINA; CHEMES, LUCÍA B.; DE PRAT-GAY, GONZALO

Cooperative RNA Recognition by a Viral Transcription Antiterminator

JOURNAL OF MOLECULAR BIOLOGY; Año: 2018 vol. 430 p. 777 - 792

ESPERANTE, SEBASTIÁN A.; ALVAREZ-PAGGI, DAMIÁN; SALGUEIRO, MARIANO; DE PRAT GAY, GONZALO

Mechanism of Tetramer Dissociation, Unfolding, and Oligomer Assembly of Pneumovirus M2-1 Transcription Antiterminators

ACS Omega; Año: 2018 vol. 3 p. 14732 - 14745

GLAVINA, JULIANA; ROMÁN, ERNESTO A.; ESPADA, ROCÍO; DE PRAT-GAY, GONZALO; CHEMES, LUCÍA B.; SÁNCHEZ, IGNACIO E.

Interplay between sequence, structure and linear motifs in the adenovirus E1A hub protein

VIROLOGY; Año: 2018 vol. 525 p. 117 - 131

BORKOSKY, SILVIA S.; CAMPOREALE, GABRIELA; CHEMES, LUCÍA B.; RISSO, MARIKENA; NOVAL, MARÍA GABRIELA; SÁNCHEZ, IGNACIO E.; ALONSO, LEONARDO G.; DE PRAT GAY, GONZALO

Hidden Structural Codes in Protein Intrinsic Disorder

BIOCHEMISTRY; Año: 2017 vol. 56 p. 5560 - 5569

FOSCALDI, SABRINA; D'ANTUONO, ALEJANDRA; NOVAL, MARÍA GABRIELA; DE PRAT GAY, GONZALO; SCOLARO, LUIS; LOPEZ, NORA

Regulation of Tacaribe Mammarenavirus Translation: Positive 5’ and Negative 3’ Elements, and Role of Key Cellular Factors.

JOURNAL OF VIROLOGY; Lugar: Washington; Año: 2017

CAMPOREALE, G.; LORENZO, J. R.; SALVATIERRA, T. E.; THOMAS, M. G.; BORKOSKY, S.; RISSO, M.; SANCHEZ, I.E.; PRAT GAY G. DE; ALONSO, L.G.

Degenerate cysteine patterns mediate two redox sensing mechanisms in the papillomavirus E7 oncoprotein

Redox Biology; Año: 2017 vol. 11 p. 38 - 50

NOVAL, M.G.; ESPERANTE, S.A.; MOLINA, I.G.; CHEMES, L.B.; DANTUR, K.I., GARCIA ALAI, M.M., VIGHI, S., PITOSSI, F., FERRARI, C. AND PRAT GAY, G. DE.

Intrinsic Disorder to Order Transitions in the Scaffold Phosphoprotein P from the Respiratory Syncytial Virus RNA Polymerase Complex

BIOCHEMISTRY; Lugar: Washington; Año: 2016 vol. 55 p. 1441 - 1454

PRETEL, E.; SANCHEZ, I.E.; FASSOLARI, M; CHEMES, L.B.; DANTUR, K.I., GARCIA ALAI, M.M., VIGHI, S., PITOSSI, F., FERRARI, C. AND PRAT GAY, G. DE.

Conformational Heterogeneity Determined by Folding and Oligomer Assembly Routes of the Interferon Response Inhibitor NS1 Protein, Unique to Human Respiratory Syncytial Virus

BIOCHEMISTRY; Lugar: Washington; Año: 2015 vol. 54 p. 5136 - 5146

CHEMES, L.B.; PRAT GAY, G DE; SANCHEZ, I.E.

Convergent evolution and mimicry of protein linear motifs in host-pathogen interactions

CURRENT OPINION IN STRUCTURAL BIOLOGY; Lugar: Londres; Año: 2015 vol. 32 p. 91 - 101

RAMIREZ, N.; GUERRA, F; CAMPOREALE, G.; QUINTANA, S.; DIAZ, L.B.; CUNEO, N; VILLACORTA HIDALGO, J.; TATTI, S.; BORKOSKY, S.; PRAT GAY G. DE; PALAORO, L.A.

Expression of E2 and E7-HPV16 proteins in pre-malignant and malignant lesions of the uterine cervix

BIOTECHNIC AND HISTOCHEMISTRY; Lugar: London; Año: 2015 vol. 19 p. 1 - 8

CHEMES, L.B.; CAMPOREALE, G.; SANCHEZ, I.E.; PRAT GAY G. DE; ALONSO, L.G.

Cysteine-rich positions outside the structural zinc motif of human papillomavirus E7 provide conformational modulation and suggest functional redox roles

BIOCHEMISTRY; Lugar: Washington; Año: 2014 vol. 53 p. 1680 - 1686

GUERRA, F; ROCHER, A.E.; VILLACORTA HIDALGO, J.; DIAZ, L.; VIGHI, S.; CARDINAL, L.; TATTI, S.; CÚNEO, N.; CAMPOREALE, G.; PRAT GAY G. DE; PALAORO, L.A.

Argentophilic nucleolus organizer region as a proliferation marker in cervical intraepithelial neoplasia grade 1 of the uterine cervix

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH; Lugar: Londres; Año: 2014 vol. 10 p. 1717 - 1724

FASSOLARI, M; CHEMES, L.B.; GALLO, M.; SMAL, C.; SANCHEZ, I.E.; DE PRAT GAY, G

Minute-timescale prolyl isomerization governs antibody recognition of an intrinsically disordered immunodominant epitope

JOURNAL OF BIOLOGICAL CHEMISTRY; Lugar: Bethesda, Maryland; Año: 2013 vol. 288 p. 13110 - 13113

CHEMES, L.B.; NOVAL, M.G.; SANCHEZ, I.E.; DE PRAT GAY, G

Folding of a cyclin box: linking multitarget binding to marginal stability, oligomerization and aggregation of the retinoblastoma tumor suppressor AB pocket domain

JOURNAL OF BIOLOGICAL CHEMISTRY; Lugar: Bethesda, Maryland; Año: 2013 vol. 288 p. 18923 - 18938

ESPERANTE, S.A.; NOVAL, M.G.; ALTIERI, T.A.; DE OLIVEIRA, G. A.; SILVA, J.L.; PRAT GAY, G. DE

Fine Modulation of the Respiratory Syncytial Virus M2-1 Protein Quaternary Structure by Reversible Zinc Removal from Its Cys3-His1 Motif

BIOCHEMISTRY; Lugar: Washington; Año: 2013 vol. 52 p. 6779 - 6789

PRETEL, E.; CAMPOREALE, G.; PRAT GAY, G DE

The Non-Structural NS1 Protein Unique to Respiratory Syncytial Virus: A Two-State Folding Monomer in Quasi-Equilibrium with a Stable Spherical Oligomer

PLOS ONE; Lugar: San Francisco; Año: 2013 vol. 8 p. 1 - 9

NOVAL, M.G.; GALLO, M.; PERRONE, S.; SALVAY, A. G.; CHEMES, L.B.; PRAT GAY, G. DE

Conformational Dissection of a Viral Intrinsically Disordered Domain Involved in Cellular Transformation.

PLOS ONE; Lugar: San Francisco; Año: 2013 vol. 8 p. 1 - 10

CERUTTI, M.L.; ALONSO, L.G.; TATTI, S.; DE PRAT GAY, G

Long-lasting immunoprotective and therapeutic effects of a hyperstable E7 oligomer based vaccine in a murine HPV tumor model

INTERNATIONAL JOURNAL OF CANCER. JOURNAL INTERNATIONAL DU CANCER.; Lugar: New York; Año: 2012 vol. 130 p. 1813 - 1820

CHEMES, L.B.; ALONSO, L.G.; NOVAL, M.G.; PRAT GAY G. DE

Circular Dichroism Techniques for the identification of Intrinsically Disordered Proteins

METHODS IN MOLECULAR BIOLOGY (CLIFTON, N.J.); Lugar: Clifton, New Jersey; Año: 2012 vol. 895 p. 387 - 404

SMAL, C.; ALONSO, L.G.; WETZLER, D.E.; HEER, A; PRAT GAY, G DE

Ordered Self-Assembly Mechanism of a Spherical Oncoprotein Oligomer Triggered by Zinc Removal and Stabilized by an Intrinsically Disordered Domain

PLOS ONE; Lugar: San Francisco; Año: 2012 vol. 7 p. 1 - 10

CHEMES, L.B.; GLAVINA, J.; FAIVOVICH, J.; PRAT GAY G. DE; SANCHEZ, I.E.

Evolution of linear motifs within the papillomavirus E7 oncoprotein

JOURNAL OF MOLECULAR BIOLOGY; Lugar: Amsterdam; Año: 2012 vol. 422 p. 336 - 346

CHEMES, L.B.; GLAVINA, J.; ALONSO, L.G.; MARINO-BUSLJE; PRAT GAY G. DE; SANCHEZ, I.E.

Sequence Evolution of the Intrinsically Disordered and Globular Domains of a Model Viral Oncoprotein

PLOS ONE; Lugar: San Francisco; Año: 2012 vol. 7 p. 1 - 9

ESPERANTE, S.A.; PARIS, G.; PRAT GAY, G. DE

Modular unfolding and dissociation of the human respiratory syncytial virus phosphoprotein p and its interaction with the m(2-1) antiterminator: a singular tetramer-tetramer interface arrangement.

BIOCHEMISTRY; Lugar: Washington; Año: 2012 vol. 51 p. 8100 - 8110

HEER, H.; ALONSO, L.G.; DE PRAT GAY, G

E6*, the 50 amino acid product of the most abundant spliced transcript of the E6 oncoprotein in high-risk human papillomavirus, is a promiscuous folder and binder

BIOCHEMISTRY; Año: 2011 vol. 50 p. 1376 - 1383

SANCHEZ, I.E.; FERREIRO, D.U.; DE PRAT GAY, G

Mutational analysis of kinetic partitioning in protein folding and protein-DNA binding

PROTEIN ENGINEERING DESIGN & SELECTION; Año: 2011 vol. 24 p. 179 - 184

ALONSO, L.; CERUTTI, M.L.; RISSO, M.; GONZALEZ, M.; CAMPOREALE, G.; DE PRAT GAY, G

DESARROLLO DE UNA VACUNA PROFILACTICA DE SEGUNDA GENERACION CONTRA EL PAPILOMAVIRUS HUMANO

MEDICINA (BUENOS AIRES); Lugar: Buenos Aires; Año: 2011 vol. 71 p. 261 - 266

CHEMES, L.; SANCHEZ, I.E.; DE PRAT GAY, G

Kinetic recognition of the retinoblastoma tumor suppressor by a specific protein target

JOURNAL OF MOLECULAR BIOLOGY; Lugar: Amsterdam; Año: 2011 vol. 412 p. 267 - 284

ESPERANTE, S.A.; CHEMES, L.B.; SANCHEZ, I.E.; DE PRAT GAY, G

The respiratory syncytial virus transcription antiterminator M2-1 is an extended, zinc binding tetramer with a strong pH dependent dissociation and a monomeric unfolding intermediate

BIOCHEMISTRY; Lugar: Washington; Año: 2011 vol. 50 p. 8529 - 8539

CHEMES, L.; SANCHEZ, I.E.; SMAL, C.; PRAT GAY G. DE

Targeting mechanism of the retinoblastoma tumor suppressor by a prototypical viral oncoprotein. Structural modularity, intrinsic disorder and phosphorylation of human papillomavirus E7

FEBS JOURNAL; Año: 2010 vol. 277 p. 973 - 988

SANCHEZ, I.E.; FERREIRO, D.U.; DELLAROLE, M.; PRAT GAY G. DE

Experimental snapshots of a protein-DNA binding landscape

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Año: 2010 vol. 107 p. 7751 - 7756

DELLAROLE, M.; SANCHEZ, I.E.; DE PRAT GAY, G

Thermodynamic basis for cooperative DNA recognition at a replication origin and transcription regulatory site

BIOCHEMISTRY; Lugar: Washington; Año: 2010 vol. 49 p. 10277 - 10286

WETZLER, D.E.; GALLO, M.; ELISEO, T.; NADRA, A.D.; FERREIRO, D.U.; SANCHEZ, I.E.; CICERO, D.O.; PRAT GAY, G. DE

A strained DNA binding helix is highly conserved for site recognition, folding nucleation and conformational modulation

BIOPOLYMERS; Año: 2009 vol. 91 p. 432 - 443

ELISEO, T.; SANCHEZ, I; NADRA, A.; DELLAROLE, M.; PACI, M.; PRAT GAY G. DE; CICERO, D.

Indirect DNA Readout on the Protein Side: Coupling between Histidine Protonation, Global Structural Cooperativity, Dynamics, and DNA Binding of the Human Papillomavirus Type 16 E2C Domain.

JOURNAL OF MOLECULAR BIOLOGY; Año: 2009 vol. 388 p. 327 - 344

DANTUR, K.; ALONSO, L.G.; CASTAÑO, E.M.; MORELLI, L.; CENTENO CROWLEY, J.M.; VIGHI, S.; PRAT GAY G. DE

Cytosolic accumulation of HPV16 E7 oligomers supports different transformation routes for the prototypic viral oncoprotein: The amyloid-cancer connection

INTERNATIONAL JOURNAL OF CANCER. JOURNAL INTERNATIONAL DU CANCER.; Año: 2009 vol. 125 p. 1902 - 1911

SMAL, C.; WETZLER, D.E.; DANTUR, K.I.; CHEMES, L.; GARCIA ALAI, M.M.; DELLAROLE, M.; ALONSO, L.G.; GASTON, K.; PRAT GAY G. DE

The human papillomavirus E7-E2 interaction mechanism in vitro reveals a finely tuned system for modulating available E7 and E2 proteins

BIOCHEMISTRY; Año: 2009 vol. 48 p. 11939 - 11949

FREIRE, E.; ODDO, C; FRAPPIER, L.; PRAT GAY, G. DE

Kinetically driven refolding of the hyperstable EBNA1 origin DNA-binding dimeric ß-barrel domain into spherical oligomers with amyloid-like properties

PROTEINS: STRUCTURE, FUNCTION AND GENETICS; Año: 2008 vol. 70 p. 450 - 461

PRAT GAY, G. DE; GASTON, K.; CICERO, D.O.

The papillomavirus E2 DNA binding domain: A unique fold with unique properties for multiple regulatory functions in the Viral life cycle

FRONTIERS IN BIOSCIENCES; Año: 2008 vol. 13 p. 6006 - 6021

SÁNCHEZ, I.; DELLAROLE, M.; GASTON, K.; PRAT GAY, G DE

Comprehensive comparison of the interaction of the E2 master regulator with its cognate target DNA sites in 73 human papillomavirus types by sequence statistics

NUCLEIC ACIDS RESEARCH; Año: 2008 vol. 36 p. 756 - 759

LLOVERA, R.E.; DE TULLIO, M.; ALONSO, L.G.; LEISSRING, M.A.; KAUFMAN, S.B.; ROHER, A.E.; PRAT GAY G. DE; MORELLI, L.; CASTAÑO, E.M.

The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid beta peptide: implications for Alzheimer disease pathogenesis

JOURNAL OF BIOLOGICAL CHEMISTRY; Año: 2008 vol. 283 p. 17039 - 17048

FERREIRO, D.U.; SANCHEZ, I; PRAT GAY G. DE

The transition state for protein-DNA recognition

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Año: 2008 vol. 105 p. 10797 - 10802

GARCÍA-ALAI, M.; DANTUR, K.; SMAL, C.; PIETRASANTA, L.; PRAT GAY, G. DE

High risk HPV E6 oncoproteins assemble into large oligomers that allow localization of endogenous species in prototypic HPV transformed cell lines.

BIOCHEMISTRY; Año: 2007 vol. 46 p. 341 - 349

WETZLER, D.; CASTAÑO, E.; PRAT GAY, G. DE

A quasi-spontaneous amyloid route in the DNA binding gene regulatory domain of the papillomavirus HPV16 E2 protein

PROTEIN SCIENCE; Año: 2007 vol. 16 p. 744 - 754

SANGUINETI, S.; CENTENO CROWLEY, J.M.; LODEIRO, M.F.; CERUTTI, M.L.; GOLDBAUM, F.; WILSON, I.; STANFIELD, R.; PRAT GAY, G. DE

Molecular basis for the recognition of a DNA immunogen by its elicited antibody.

JOURNAL OF MOLECULAR BIOLOGY; Año: 2007 vol. 370 p. 183 - 195

FALCONI, M.; SANTOLAMAZZA, A.; ELISEO, T.; PRAT GAY, G. DE; CICERO, D.; DESIDERI, S.

Molecular dynamics of the DNA binding domain of the papillomavirus E2 transcriptional regulator uncovers differential properties for DNA target accommodation.

The FEBS Journal; Año: 2007 vol. 274 p. 2385 - 2395

GARCÍA ALAI, M.; ALONSO, L.; PRAT GAY, G. DE

The N-terminal module of HPV16 E7 is an intrinsically disordered domain that confers conformational and recognition plasticity to the oncoprotein.

BIOCHEMISTRY; Año: 2007 vol. 46 p. 10405 - 10412

DELLAROLE, M.; SÁNCHEZ, I.; FREIRE, E.; PRAT GAY, G. DE

Increased stability and DNA site discrimination of single chain variants of the dimeric ß-barrel DNA binding domain of the human papillomavirus E2 transcriptional regulator.

BIOCHEMISTRY; Año: 2007 vol. 46 p. 12441 - 12450

GARCÍA ALAI, M.; GALLO, M.; SALAME, M.; WETZLER, D.; MCBRIDE, A.; CICERO, D.; PACI, M.; PRAT GAY, G. DE

Molecular basis for phosphorylation dependent PEST mediated protein turnover.

STRUCTURE WITH FOLDING & DESIGN.; Año: 2006 vol. 14 p. 309 - 319

ALONSO, L.; SMAL, C.; GARCÍA ALAI, M.; CHEMES, L.; SALAME, M.; PRAT GAY, G. DE

The chaperone holdase activity of human papillomavirus E7 oncoprotein

BIOCHEMISTRY; Año: 2006 p. 657 - 667

CICERO, D.; NADRA, A.; ELISEO, T.; DELLAROLE, M.; PACI, M.; PRAT GAY, G. DE

Structural and thermodynamic basis for the enhanced transcriptional control by the human papillomavirus strain-16 E2 protein

BIOCHEMISTRY; Año: 2006 vol. 45 p. 6551 - 6560

ODDO, C.; FREIRE, E.; FRAPPIER, L.; PRAT GAY, G. DE

Mechanism of DNA recognition at a viral replication origin

JOURNAL OF BIOLOGICAL CHEMISTRY; Año: 2006 vol. 281 p. 26893 - 26903

CERUTTI, M.L., FERREIRO, D.U., GOLDBAUM, F.A. AND PRAT GAY, G. DE

Antibody recognition of a flexible epitope at the DNA binding site of the human papillomavirus transcriptional regulator E2

BIOCHEMISTRY; Año: 2006 vol. 45 p. 15520 - 15528

CERUTTI, M.L., ZAREBSKI, L.M., PRAT GAY, G. DE, AND GOLDBAUM, F.A.

A viral DNA-binding domain elicits anti-DNA antibodies of different specificities.

MOLECULAR IMMUNOLOGY; Año: 2005 vol. 42 p. 327 - 333

MORELLI, L., LLOVERA R.E., ALONSO, L.G., FRANGIONE, B., PRAT GAY, G. DE, GHISO, J. AND CASTAÑO, E.M.

Insulin-degrading enzyme degrades amyloid peptides associated with British and Danish familial dementia.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS; Año: 2005 vol. 332 p. 806 - 814

PRAT-GAY, G. DE, NADRA, A.D., CORRALES-IZQUIERDO, F.J., ALONSO, L.G., FERREIRO, D.U. AND MOK, Y.K

The folding mechanism of a dimeric ß-barrel domain.

JOURNAL OF MOLECULAR BIOLOGY; Año: 2005 vol. 351 p. 672 - 682

FERREIRO, D.U., DELLAROLE, M., NADRA, A.D. AND PRAT GAY, G. DE

Free energy contributions to direct readout of a DNA sequence.

JOURNAL OF BIOLOGICAL CHEMISTRY; Año: 2005 vol. 280 p. 32480 - 32484

ALONSO, G., GARCÍA-ALAI, M., SMAL, C., CENTENO-CROWLEY, J.M., IACONO, R., CASTAÑO, E., GUALFETTI, P., AND PRAT-GAY, G. DE

The HPV16 E7 viral oncoprotein self-assembles into defined spherical oligomers.

BIOCHEMISTRY; Año: 2004 vol. 43 p. 3310 - 3317

PENROSE, K.J., GARCÍA ALAI, M., PRAT GAY, G. DE AND MCBRIDE, A.A.

CK2 phosphorylation-induced conformational switch triggers degradation of the papillomavirus E2 protein.

JOURNAL OF BIOLOGICAL CHEMISTRY; Año: 2004 vol. 279 p. 22430 - 22439

NADRA, A., ELISEO, T., MOK, Y-K., ALMEIDA, F.L., BYCROFT, M., PACI, M., PRAT GAY, G. DE AND CICERO, D.

Solution Structure of the HPV-16 E2 DNA binding domain, a transcriptional regulator with a dimeric ß-barrel fold.

Journal of Biomolecular NMR; Año: 2004 vol. 30 p. 211 - 214

CARAMELO, J.J., CASTRO ,O.A., PRAT GAY, G. DE AND, PARODI, A.J.

The endoplasmic reticulum glucosyltransferase recognizes nearly native glycoprotein folding intermediates.

JOURNAL OF BIOLOGICAL CHEMISTRY; Año: 2004 vol. 279 p. 46280 - 46285

FERREIRO, D.U.; PRAT GAY, G DE

A protein-DNA binding mechanism proceeds through multi-state or two-state parallel pathways.

JOURNAL OF MOLECULAR BIOLOGY; Año: 2003 vol. 331 p. 89 - 99

DI PIETRO, S; CENTENO CROWLEY, J.M.; CERUTTI, M.L.; LODEIRO, M.F.; FERREIRO, D.U.; ALONSO, L.; SCHWARTZ, F.P.; GOLDBAUM, F.; PRAT GAY G. DE

Specific antibody-DNA interaction: a novel strategy for tight DNA recognition.

BIOCHEMISTRY; Año: 2003 vol. 42 p. 6218 - 6227

CERUTTI, M.L.; CENTENO CROWLEY, J.M.; PRAT GAY, G DE; GOLDBAUM, F.

Antibody response to a viral transcriptional regulator.

FEBS LETTERS; Año: 2003 vol. 534 p. 202 - 206

CARAMELO, J.J.; CASTRO ,O.A.; PRAT GAY G. DE; PARODI, AJ

UDP-Glc:glycoprotein glucosyltransferase recognizes structured and solvent accessible hydrophobic patches in molten globule-like folding intermediates.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Año: 2003 vol. 100 p. 86 - 91

ALONSO, L.; GARCÍA ALAI, M.M.; NADRA, A.; LAPEÑA, A.N.; ALMEIDA, F.L.; GUALFETTI, P.; PRAT GAY G. DE

High-risk (HPV16) human papillomavirus E7 oncoprotein is highly stable and extended, with conformational transitions that could explain its multiple cellular binding partners

BIOCHEMISTRY; Año: 2002 vol. 41 p. 10510 - 10518

NEIRA, J.L.; GONZALEZ, C.; TOIRON, C.; PRAT GAY G. DE; RICO, M.

Three-dimensional solution structure and stability of thioredoxin m from spinach

BIOCHEMISTRY; Año: 2001 vol. 40 p. 15246 - 15256

CERUTTI, M.L.; CENTENO CROWLEY, J.M.; GOLDBAUM, F.; PRAT GAY G. DE

Generation of sequence-specific, high affinity anti-DNA antibodies.

JOURNAL OF BIOLOGICAL CHEMISTRY; Año: 2001 vol. 276 p. 12769 - 12773

BARBOSA, JA; PINHEIRO, CB; PRAT GAY G. DE; POLIKARPOV I

Crystallization and X-Ray data analysis of the extended DNA-binding domain of the Bovine papillomavirus type I protein

PROTEIN AND PEPTIDE LETTERS; Año: 2001 vol. 8 p. 323 - 326

FERREIRO, D.U.; LIMA, L.M.; NADRA, A.; ALONSO, L.G.; GOLDBAUM, F.A.; PRAT GAY G. DE

Distinctive cognate sequence discrimination, bound DNA conformation, and binding modes in the E2 C-terminal domains from prototype human and bovine papillomavirusesferr

BIOCHEMISTRY; Año: 2000 vol. 39 p. 14692 - 14701

MOK, Y.K; ALONSO, L.G.; LIMA, L.M.; BYCROFT, M.; PRAT GAY G. DE

Folding of a dimeric beta-barrel: residual structure in the urea denatured state of the human papillomavirus E2 DNA binding domain.

PROTEIN SCIENCE; Año: 2000 vol. 9 p. 799 - 811

MOHANA-BORGES, R.; SILVA, J.L.; RUIZ-SANZ, J.; PRAT GAY G. DE

Folding of a pressure-denatured model protein.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Año: 1999 vol. 96 p. 7888 - 7893

MOHANA-BORGES, R.; SILVA, J.L.; PRAT GAY G. DE

Protein folding in the absence of chemical denaturants. Reversible pressure denaturation of the noncovalent complex formed by the association of two protein fragments.

JOURNAL OF BIOLOGICAL CHEMISTRY; Año: 1999 vol. 274 p. 7732 - 7740

FOGUEL, D.; SILVA, J.L.; PRAT GAY G. DE

Characterization of a partially folded monomer of the DNA-binding domain of human papillomavirus E2 protein obtained at high pressure

JOURNAL OF BIOLOGICAL CHEMISTRY; Año: 1998 vol. 273 p. 9050 - 9057

LADURNER, A.G.; ITZHAKI, L.S.; PRAT GAY G. DE; FERSHT, A.R.

Complementation of peptide fragments of the single domain protein chymotrypsin inhibitor 2.

JOURNAL OF MOLECULAR BIOLOGY; Año: 1997 vol. 273 p. 317 - 329

LIMA, L.M.; PRAT GAY G. DE

Conformational changes and stabilization induced by ligand binding in the DNA-binding domain of the E2 protein from human papillomavirus

JOURNAL OF BIOLOGICAL CHEMISTRY; Año: 1997 vol. 272 p. 19295 - 19303

PRAT GAY, G DE

Conformational preferences of a peptide corresponding to the major antigenic determinant of foot-and-mouth disease virus: implications for peptide-vaccine approaches.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS; Año: 1997 vol. 341 p. 360 - 369

NEIRA, J.L.; ITZHAKI, L.S.; LADURNER, A.G.; DAVIS, B.; PRAT GAY, G DE; FERSHT, A.R.

Following co-operative formation of secondary and tertiary structure in a single protein module.

JOURNAL OF MOLECULAR BIOLOGY; Año: 1997 vol. 268 p. 185 - 197

PRAT GAY G. DE

Spectroscopic characterization of the growing polypeptide chain of the barley chymotrypsin inhibitor-2

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS; Año: 1996 vol. 335 p. 1 - 7

PRAT GAY G. DE

Association of complementary fragments and the elucidation of protein folding pathways

PROTEIN ENGINEERING; Año: 1996 vol. 9 p. 843 - 847

MOK, Y.K; BYCROFT, M.; PRAT GAY, G DE

The dimeric DNA binding domain of the human papillomavirus E2 protein folds through a monomeric intermediate which cannot be native-like.

NATURE STRUCT. BIOL.; Año: 1996 vol. 3 p. 711 - 717

MOK, Y.K; PRAT GAY, G DE; BUTLER, P.J.; BYCROFT, M.

Equilibrium dissociation and unfolding of the dimeric human papillomavirus strain-16 E2 DNA-binding domain.

PROTEIN SCIENCE; Año: 1996 vol. 5 p. 310 - 319

NEIRA, J.L.; DAVIS, B.; LADURNER, A.G.; BUCKLE, A.M.; PRAT GAY G. DE; FERSHT, A.R.

Towards the complete structural characterization of a protein folding pathway: the structures of the denatured, transition and native states for the association/folding of two complementary fragments of cleaved chymotrypsin inhibitor 2. Direct evidence fo

STRUCTURE WITH FOLDING & DESIGN.; Año: 1996 vol. 1 p. 189 - 208

PRAT GAY, G DE; RUIZ-SANZ, J.; NEIRA, J.L.; CORRALES, F.J.; OTZEN, D.E.; LADURNER, A.G.; FERSHT, A.R.

Conformational pathway of the polypeptide chain of chymotrypsin inhibitor-2 growing from its N terminus in vitro. Parallels with the protein folding pathway.

JOURNAL OF MOLECULAR BIOLOGY; Año: 1995 vol. 254 p. 968 - 979

ITZHAKI, L.S.; NEIRA, J.L.; RUIZ-SANZ, J.; PRAT GAY, G DE; FERSHT, A.R.

Search for nucleation sites in smaller fragments of chymotrypsin inhibitor 2

JOURNAL OF MOLECULAR BIOLOGY; Año: 1995 vol. 254 p. 289 - 304

PRAT GAY, G DE; RUIZ-SANZ, J.; NEIRA, J.L.; ITZHAKI, L.S.; FERSHT, A.R.

Folding of a nascent polypeptide chain in vitro: cooperative formation of structure in a protein module

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Año: 1995 vol. 92 p. 3683 - 3686

RUIZ-SANZ, J.; PRAT GAY G. DE; OTZEN, D.E.; FERSHT, A.R.

Protein fragments as models for events in protein folding pathways: protein engineering analysis of the association of two complementary fragments of the barley chymotrypsin inhibitor 2 (CI-2).

BIOCHEMISTRY; Año: 1995 vol. 34 p. 1695 - 1701

PRAT GAY, G DE; RUIZ-SANZ, J.; DAVIS, B.; FERSHT, A.R.

The structure of the transition state for the association of two fragments of the barley chymotrypsin inhibitor 2 to generate native-like protein: implications for mechanisms of protein folding

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Año: 1994 vol. 91 p. 10943 - 10946

PRAT GAY, G DE

Contribution of a proline residue and a salt bridge to the stability of a type I reverse turn in chymotrypsin inhibitor-2

PROTEIN ENGINEERING; Año: 1994 vol. 7 p. 103 - 108

PRAT GAY, G DE; RUIZ-SANZ, J.; FERSHT, A.R.

Generation of a family of protein fragments for structure-folding studies. 2. Kinetics of association of the two chymotrypsin inhibitor-2 fragments.

BIOCHEMISTRY; Año: 1994 vol. 33 p. 7964 - 7970

PRAT GAY, G DE; FERSHT, A.R.

Generation of a family of protein fragments for structure-folding studies. 1. Folding complementation of two fragments of chymotrypsin inhibitor-2 formed by cleavage at its unique methionine residue

BIOCHEMISTRY; Año: 1994 vol. 33 p. 7957 - 7963

PRAT GAY, G. DE; DUCKWORTH, H.W.; FERSHT, A.R.

Modification of the amino acid specificity of tyrosyl-tRNA synthetase by protein engineering

FEBS LETTERS; Año: 1993 vol. 318 p. 167 - 171

PRAT GAY G. DE; PALADINI, A.; STEIN, M.; WOLOSIUK, R. A.

The effect of high hydrostatic pressure on the modulation of regulatory enzymes from spinach chloroplasts

JOURNAL OF BIOLOGICAL CHEMISTRY; Año: 1991 vol. 266 p. 20913 - 20921

PRAT GAY G. DE; WOLOSIUK, R. A.

Differential reactivity of chloroplast fructose-1,6-bisphosphatase to Woodward's reagent K and diethylpyrocarbonate

BIOCHIMICA AND BIOPHYSICA ACTA; Año: 1987 vol. 973 p. 457 - 464