INVESTIGADORES
DE MORENO Maria Alejandra
artículos
Título:
Adjuvant effect of a probiotic fermented milk in the protection against Salmonella enteritidis serovar Typhimurium infection
Autor/es:
A. DE MORENO DE LEBLANC; C. MALDONADO GALDEANO; C. DOGI; E. CARMUEGA; R. WEILL; G. PERDIGON
Revista:
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
Editorial:
BIOLIFE SAS
Referencias:
Año: 2010 vol. 23 p. 1235 - 1244
ISSN:
0394-6320
Resumen:
Probiotics may offer protection against Salmonella enteritidis serovar Typhimurium infection
via different mechanisms. The aim of this study was to investigate, using mouse models, the
effect of the administration of fermented milk containing the probiotic bacteria L. casei DN-
114 001 in the protection against Salmonella enteritidis serovar Typhimurium when this
product is administered continuously before and after infection or only post infection. The
adjuvant effect of this probiotic fermented milk (PFM) against S. Typhimurium was also
evaluated in newborn mice, whose mothers received the PFM during the suckling period or
their offspring after weaning. The results obtained showed that PFM administration after
Salmonella enteritidis serovar Typhimurium infection
via different mechanisms. The aim of this study was to investigate, using mouse models, the
effect of the administration of fermented milk containing the probiotic bacteria L. casei DN-
114 001 in the protection against Salmonella enteritidis serovar Typhimurium when this
product is administered continuously before and after infection or only post infection. The
adjuvant effect of this probiotic fermented milk (PFM) against S. Typhimurium was also
evaluated in newborn mice, whose mothers received the PFM during the suckling period or
their offspring after weaning. The results obtained showed that PFM administration after
L. casei DN-
114 001 in the protection against Salmonella enteritidis serovar Typhimurium when this
product is administered continuously before and after infection or only post infection. The
adjuvant effect of this probiotic fermented milk (PFM) against S. Typhimurium was also
evaluated in newborn mice, whose mothers received the PFM during the suckling period or
their offspring after weaning. The results obtained showed that PFM administration after
Salmonella enteritidis serovar Typhimurium when this
product is administered continuously before and after infection or only post infection. The
adjuvant effect of this probiotic fermented milk (PFM) against S. Typhimurium was also
evaluated in newborn mice, whose mothers received the PFM during the suckling period or
their offspring after weaning. The results obtained showed that PFM administration after
S. Typhimurium was also
evaluated in newborn mice, whose mothers received the PFM during the suckling period or
their offspring after weaning. The results obtained showed that PFM administration after
Salmonella infection was useful to decrease the severity of the infection. The best effect was
obtained with continuous PFM administration. In the newborn mice model, PFM
administration to the newborn mice after weaning showed the best effect against the pathogen.
PFM administration to the mother during the suckling period was beneficial against this
enterophatogen when their offspring did not receive probiotics after weaning. Continuous
PFM administration to adult mice (before and after infection) was important to maintain the
intestinal barrier and the immune surveillance in optimal conditions to diminish the pathway
of entrance of Salmonella and the spread of this pathogen to deeper tissues. In the newborn
mice model, it was observed that PFM administration to the offsprings after weaning or their
mother during suckling period had a protective effect against Salmonella infection, however in
the mice from mothers that received PFM during nursing were fed with PFM after weaning,
we found a down regulated immune maturity, that was not protective against this infection.
infection was useful to decrease the severity of the infection. The best effect was
obtained with continuous PFM administration. In the newborn mice model, PFM
administration to the newborn mice after weaning showed the best effect against the pathogen.
PFM administration to the mother during the suckling period was beneficial against this
enterophatogen when their offspring did not receive probiotics after weaning. Continuous
PFM administration to adult mice (before and after infection) was important to maintain the
intestinal barrier and the immune surveillance in optimal conditions to diminish the pathway
of entrance of Salmonella and the spread of this pathogen to deeper tissues. In the newborn
mice model, it was observed that PFM administration to the offsprings after weaning or their
mother during suckling period had a protective effect against Salmonella infection, however in
the mice from mothers that received PFM during nursing were fed with PFM after weaning,
we found a down regulated immune maturity, that was not protective against this infection.
Salmonella and the spread of this pathogen to deeper tissues. In the newborn
mice model, it was observed that PFM administration to the offsprings after weaning or their
mother during suckling period had a protective effect against Salmonella infection, however in
the mice from mothers that received PFM during nursing were fed with PFM after weaning,
we found a down regulated immune maturity, that was not protective against this infection.
Salmonella infection, however in
the mice from mothers that received PFM during nursing were fed with PFM after weaning,
we found a down regulated immune maturity, that was not protective against this infection.