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Rescue of secretion of rare‐disease‐associated misfolded mutant glycoproteins in UGGT1 knock‐out mammalian cells

TRAFFIC; Año: 2024 vol. 25

GUAY, KEVIN P.; IBBA, ROBERTA; KIAPPES, J.L.; VASILJEVI?, SNE?ANA; BONÌ, FRANCESCO; DE BENEDICTIS, MARIA; ZENI, ILARIA; LE CORNU, JAMES D.; HENSEN, MARIO; CHANDRAN, ANU V.; KANTSADI, ANASTASSIA L.; CAPUTO, ALESSANDRO T.; BLANCO CAPURRO, JUAN I.; MODENUTTI, CARLOS P.; HEBERT, DANIEL N.; ZITZMANN, NICOLE; ROVERSI, PIETRO

A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint

iScience; Año: 2023 vol. 26

GUIJARRO, MARIA V.; KELLISH, PATRICK C.; DIB, PETER E.; PACIARONI, NICHOLAS G.; NAWAB, AKBAR; ANDRING, JACOB; KULEMINA, LIDIA; BORRERO, NICHOLAS V.; MODENUTTI, CARLOS; FEELY, MICHAEL; NASRI, ELHAM; SEIFERT, ROBERT P.; LUO, XIAOPING; BENNETT, RICHARD L.; SHABASHVILI, DANIIL; LICHT, JONATHAN D.; MCKENNA, ROBERT; ROITBERG, ADRIAN; HUIGENS, ROBERT W.; KAYE, FREDERIC J.; ZAJAC-KAYE, MARIA

First-in-class multifunctional TYMS nonclassical antifolate inhibitor with potent in vivo activity that prolongs survival

JCI Insight; Año: 2023 vol. 8

ZHANG, HENGXI; MODENUTTI, CARLOS; NEKKANTI, YELHA PHANI KUMAR; DENIS, MAXIME; BERMEJO, IRIS A.; LEFÈBRE, JONATHAN; CHE, KATERYNA; KIM, DONGYOON; KAGELMACHER, MARTEN; KURZBACH, DENNIS; NAZARÉ, MARC; RADEMACHER, CHRISTOPH

Identification of the Allosteric Binding Site for Thiazolopyrimidine on the C-Type Lectin Langerin

ACS CHEMICAL BIOLOGY; Año: 2022 vol. 17 p. 2728 - 2733

MARTÍN, MARIANO; BRUNELLO, FRANCO G.; MODENUTTI, CARLOS P.; NICOLA, JUAN P.; MARTI, MARCELO A.

MotSASi: Functional short linear motifs (SLiMs) prediction based on genomic single nucleotide variants and structural data

BIOCHIMIE; Año: 2022 vol. 197 p. 59 - 73

WAWRZINEK, ROBERT; WAMHOFF, EIKE-CHRISTIAN; LEFEBRE, JONATHAN; RENTZSCH, MAREIKE; BACHEM, GUNNAR; DOMENICONI, GARY; SCHULZE, JESSICA; FUCHSBERGER, FELIX F.; ZHANG, HENGXI; MODENUTTI, CARLOS; SCHNIRCH, LENNART; MARTI, MARCELO A.; SCHWARDT, OLIVER; BRÄUTIGAM, MARIA; GUBERMAN, MÓNICA; HAUCK, DIRK; SEEBERGER, PETER H.; SEITZ, OLIVER; TITZ, ALEXANDER; ERNST, BEAT; RADEMACHER, CHRISTOPH

A Remote Secondary Binding Pocket Promotes Heteromultivalent Targeting of DC-SIGN

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY; Lugar: Washington; Año: 2021 vol. 143 p. 18977 - 18988

SERRAL, FEDERICO; CASTELLO, FLORENCIA A.; SOSA, EZEQUIEL J.; PARDO, AGUSTÍN M.; PALUMBO, MIRANDA CLARA; MODENUTTI, CARLOS; PALOMINO, MARÍA MERCEDES; LAZAROWSKI, ALBERTO; AUZMENDI, JERÓNIMO; RAMOS, PABLO IVAN P.; NICOLÁS, MARISA F.; TURJANSKI, ADRIÁN G.; MARTÍ, MARCELO A.; FERNÁNDEZ DO PORTO, DARÍO

From Genome to Drugs: New Approaches in Antimicrobial Discovery

Frontiers in Pharmacology; Lugar: lausana; Año: 2021 vol. 12

MARTÍN, MARIANO; MODENUTTI, CARLOS PABLO; GIL ROSAS, MAUCO LUCAS; PEYRET, VICTORIA; GEYSELS, ROMINA CELESTE; BERNAL BARQUERO, CARLOS EDUARDO; SOBRERO, GABRIELA; MUÑOZ, LILIANA; SIGNORINO, MALVINA; TESTA, GRACIELA; MIRAS, MIRTA BEATRIZ; MASINI-REPISO, ANA MARÍA; CALCATERRA, NORA BEATRIZ; COUX, GABRIELA; CARRASCO, NANCY; MARTÍ, MARCELO ADRIÁN; NICOLA, JUAN PABLO

A Novel SLC5A5 Variant Reveals the Crucial Role of Kinesin Light Chain 2 in Thyroid Hormonogenesis

JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM; Año: 2021 vol. 106 p. 1867 - 1881

CARABALLO, DIEGO A.; BUZZI, LUCILA I.; MODENUTTI, CARLOS P.; ACOSTA-MONTALVO, ANA; CASTRO, OLGA A.; ROSSI, MARÍA S.

Origin and Evolution of Two Independently Duplicated Genes Encoding UDP- Glucose: Glycoprotein Glucosyltransferases in Caenorhabditis and Vertebrates

G3: Genes|Genomes|Genetics; Año: 2020 vol. 10 p. 755 - 768

MODENUTTI, CARLOS PABLO; BLANCO CAPURRO, JUAN I.; IBBA ROBERTA; MARTI, MARCELO A; ZITZMANN, NICOLE ; ROVERSI, PIETRO

Clamping, bending, and twisting inter-domain motions in the misfold-recognizing portion of UDP-glucose:glycoprotein glucosyltransferase

structure; Lugar: Cambridge; Año: 2020

CEVALLOS, CINTIA ; CULASSO, ANDRÉS; MODENUTTI, CARLOS PABLO; GUN, ANA ; SUED, OMAR ; AVILA, MARÍA M ; FLICHMAN, DIEGO ; DELPINO, M VICTORIA ; QUARLERI, JORGE

Longitudinal characterization of HIV-1 pol-gene in treatment-naïve men-who-have-sex-with-men from acute to chronic infection stages

heliyon; Lugar: Cambridge; Año: 2020

MODENUTTI, CARLOS P.; CAPURRO, JUAN I. BLANCO; DI LELLA, SANTIAGO; MARTÍ, MARCELO A.

The Structural Biology of Galectin-Ligand Recognition: Current Advances in Modeling Tools, Protein Engineering, and Inhibitor Design

Frontiers in Chemistry; Año: 2019 vol. 7

GONZÁLEZ-LEBRERO, RODOLFO M.; DEFELIPE, LUCAS; MODENUTTI, CARLOS; ROITBERG, ADRIAN E.; BATASTINI, NICOLAS A.; NOGUERA, MARTÍN E.; SANTOS, JAVIER; ROMAN, ERNESTO A.

Folding and Dynamics Are Strongly pH-Dependent in a Psychrophile Frataxin

JOURNAL OF PHYSICAL CHEMISTRY B - (Print); Año: 2019 vol. 123 p. 7676 - 7686

ARCON, JUAN PABLO; DEFELIPE, LUCAS A.; LOPEZ, ELIAS D.; BURASTERO, OSVALDO; MODENUTTI, CARLOS P.; BARRIL, XAVIER; MARTI, MARCELO A.; TURJANSKI, ADRIAN G.

Cosolvent-Based Protein Pharmacophore for Ligand Enrichment in Virtual Screening

JOURNAL OF CHEMICAL INFORMATION AND MODELING; Año: 2019 vol. 59 p. 3572 - 3583

ARCON, JUAN PABLO; MODENUTTI, CARLOS P; AVENDAÑO, DEMIAN; LOPEZ, ELIAS D; DEFELIPE, LUCAS A; AMBROSIO, FRANCESCA ALESSANDRA; TURJANSKI, ADRIAN G; FORLI, STEFANO; MARTI, MARCELO A

AutoDock Bias: improving binding mode prediction and virtual screening using known protein–ligand interactions

BIOINFORMATICS (OXFORD, ENGLAND); Año: 2019

MARTÍN, MARIANO; MODENUTTI, CARLOS PABLO; PEYRET, VICTORIA; GEYSELS, ROMINA CELESTE; DARROUZET, ELISABETH; POURCHER, THIERRY; MASINI-REPISO, ANA MARÍA; MARTÍ, MARCELO ADRIÁN; CARRASCO, NANCY; NICOLA, JUAN PABLO

A carboxy-terminal monoleucine-based motif participates in the basolateral targeting of the Na+/I- symporter

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FINA MARTIN, JOAQUINA; PALOMINO, MARIA MERCEDES; CUTINE, ANABELLA M.; MODENUTTI, CARLOS P.; FERNÁNDEZ DO PORTO, DARIO A.; ALLIEVI, MARIANA C.; ZANINI, SOFIA H.; MARIÑO, KARINA V.; BARQUERO, ANDREA A.; RUZAL, SANDRA M.

Exploring lectin-like activity of the S-layer protein of Lactobacillus acidophilus ATCC 4356

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY; Año: 2019 vol. 103 p. 4839 - 4857

BLANCO CAPURRO, JUAN I.; DI PAOLA, MATIAS; GAMARRA, MARCELO DANIEL; MARTÍ, MARCELO A.; MODENUTTI, CARLOS P

An efficient use of X-ray information, homology modeling, molecular dynamics and knowledge-based docking techniques to predict protein-monosaccharide complexes

GLYCOBIOLOGY; Año: 2018 vol. 29 p. 124 - 136

DEFELIPE, LUCAS A.; ARCON, JUAN PABLO; MODENUTTI, CARLOS P.; MARTI, MARCELO A.; TURJANSKI, ADRIÁN G.; BARRIL, XAVIER

Solvents to fragments to drugs: MD applications in drug design

MOLECULES; Año: 2018 vol. 23

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VarQ: A Tool for the Structural and Functional Analysis of Human Protein Variants

Frontiers in Genetics; Año: 2018 vol. 9

PENAS, FEDERICO NICOLÁS; CARTA, DAVIDE; DMYTRENKO, GANNA; MIRKIN, GERADO A.; MODENUTTI, CARLOS PABLO; CEVEY, ÁGATA CAROLINA; RADA, MARIA JIMENA; FERLIN, MARIA GRAZIA; SALES, MARÍA ELENA; GOREN, NORA BEATRIZ

Treatment with a New Peroxisome Proliferator-Activated Receptor Gamma Agonist, Pyridinecarboxylic Acid Derivative, Increases Angiogenesis and Reduces Inflammatory Mediators in the Heart of Trypanosoma cruzi-Infected Mice

Frontiers in Immunology; Año: 2017 vol. 8

CASTRILLO, MARÍA LORENA; BICH, GUSTAVO ÁNGEL; MODENUTTI, CARLOS; TURJANSKI, ADRIÁN; ZAPATA, PEDRO DARÍO; VILLALBA, LAURA LIDIA

First Whole-Genome Shotgun Sequence of a Promising Cellulase Secretor, Trichoderma koningiopsis Strain POS7

Genome Announcements; Año: 2017 vol. 5

RADUSKY, LEANDRO; RUIZ-CARMONA, SERGIO; MODENUTTI, CARLOS; BARRIL, XAVIER; TURJANSKI, ADRIAN G.; MARTÍ, MARCELO A.

LigQ : A Webserver to Select and Prepare Ligands for Virtual Screening

JOURNAL OF CHEMICAL INFORMATION AND MODELING; Lugar: Washington; Año: 2017 vol. 57 p. 1741 - 1746

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Molecular Dynamics in Mixed Solvents Reveals Protein-Ligand Interactions, Improves Docking and Allows Accurate Binding Free Energy Predictions

JOURNAL OF CHEMICAL INFORMATION AND MODELING; Lugar: Washington; Año: 2017

LOPEZ, E; ARCON, J; GAUTO, D; PETRUK, A; MODENUTTI, C; DUMAS, V; MARTI, MARCELO A; TURJANSKI, ADRIAN G

WATCLUST: a tool for improving the design of drugs based on protein-water interactions

BIOINFORMATICS (OXFORD, ENGLAND); Lugar: Oxford; Año: 2015

MODENUTTI, C; GAUTO, D; RADUSKY, L; BLANCO, J

Using crystallographic water properties for the analysis and prediction of lectin?carbohydrate complex structures

GLYCOBIOLOGY; Lugar: Oxford; Año: 2014

GAUTO, D; MODENUTTI, C; DUMAS, V; ALVAREZ, L

DETERMINING FREE ENERGIES OF PROTEIN-LIGAND BINDING AND ASSOCIATION/ DISSOCIATION PROCESSES USING COMPUTER SIMULATIONS

World Research Journal of Peptide and Protein; Año: 2012

GAUTO, D; PETRUK, A; MODENUTTI, C; BLANCO, J

Solvent structure improves docking prediction in lectin?carbohydrate complexes

GLYCOBIOLOGY; Lugar: Oxford; Año: 2012