Effectiveness of computerized cognitive training in patients with diagnosis of mild cognitive impairment (MCI) using an argentinian videogaming platform: a double-blind randomized trial in Mar del Plata.

MARÍA EMILIA CLÉMENT; FERNANDA PELOSO; MARÍA FLORENCIA SICA; CARLA HOLGADO; MELINA VLADISAUSKAS; DANIELA MACARIO CABRAL; MIGUEL A. MARTIN; PABLO IOLI; ANDREA P. GOLDIN

Congreso; XXXVI Reunión de la Sociedad Argentina de Investigación en Neurociencias (SAN); 2021

Dementia is today one of the leading causes of disability. In Argentina, 23% of elderly people presented somecognitive impairment before the pandemic and it is estimated that prevalence increased with the lockdown.Mate Marote (MM) is an Argentine open source software specifically designed to train executive functions. Itwas tested in 5-8 year olds with excellent results. We have already evaluated the feasibility of the platform andmade changes to improve its usability. Given the current needs, it is especially important to evaluate theefficacy of this tool en MCI. We are conducting a double-blind, randomized, controlled trial. A total of 60patients >65 years with a diagnosis of MCI will be recruited and randomly assigned (1:1)to either the trainedgroup or the control group. The trained group receives 60 individual sessions of ECC in 6 months. Assessmentson cognitive abilities were conducted at baseline (T0) immediately after the intervention (T1) and six monthsafter the intervention (T2) by an investigator who is blind to treatment assignment. The change in theseassessments is the primary outcome measure but we evaluate different aspects of daily living as well. So far 35patients have been recruited. The mean age is 76.9 (SD±5.6). 65% are women.The mean schooling is 11.17years (SD±4.7). To date, only 6 patients have completed the comparative evaluation (T0 and T1), so thestatistical calculations of the hypothesis test will not yet be performed.