INVESTIGADORES
GRAMAJO Hugo Cesar
artículos
Título:
Lipid metabolism and its implication in mycobacteria–host interaction
Autor/es:
GAGO, GABRIELA; DIACOVICH, LAUTARO; GRAMAJO, HUGO
Revista:
CURRENT OPINION IN MICROBIOLOGY
Editorial:
CURRENT BIOLOGY LTD
Referencias:
Año: 2018 vol. 41 p. 36 - 42
ISSN:
1369-5274
Resumen:
The complex lipids present in the cell wall of Mycobacteriumtuberculosis (Mtb) act as major effector molecules that activelyinteract with the host, modulating its metabolism andstimulating the immune response, which in turn affects thephysiology of both, the host cell and the bacilli. Lipids from thehost are also nutrient sources for the pathogen and definethe fate of the infection by modulating lipid homeostasis.Although new technologies and experimental models ofinfection have greatly helped understanding the differentaspects of the host?pathogen interactions at the lipid level,the impact of this interaction in the Mtb lipid regulation is stillincipient, mainly because of the low background knowledge inthis area of research.
