INVESTIGADORES
GRAMAJO Hugo Cesar
artículos
Título:
Heterologous production of polyketides in bacteria
Autor/es:
E. RODRÍGUEZ, HG. MENZELLA AND H. GRAMAJO.
Revista:
METHODS IN ENZYMOLOGY.
Editorial:
ELSEVIER ACADEMIC PRESS INC
Referencias:
Año: 2009 vol. 459 p. 339 - 364
ISSN:
0076-6879
Resumen:
Polyketide natural products are among the most important microbial metabolites
in human medicine and are widely used to treat both acute and degenerative
diseases. The need to develop new drugs has prompted the idea of using
heterologous systems for the expression of polyketide biosynthetic pathways.
The basic idea behind this approach is to use heterologous bacterial systems
with better growth and genetic characteristics that could support better
production of a certain compound than the original host or that could
allow the generation of novel analogues through combinatorial biosynthesis