GUANTAY, LAURA; GARRO, CINTIA; SIRI, SEBASTIÁN; PANSA, MARÍA FLORENCIA; GHIDELLI-DISSE, SONJA; PAVIOLO, NATALIA; RACCA, ANA; NICOTRA, VIVIANA; RADU, CAIUS; BOCCO, JOSÉ LUIS; FELICE, ROSANA; JANSSON, KEITH H.; REMLINGER, KATJA; AMADOR, ALEJANDRO; STRONACH, EUAN; COLEMAN, KEVIN; MUELBAIER, MARCEL; DREWES, GERARD; GLOGER, ISRO; MADAUSS, KEVIN; GARCÍA, MANUELA; GOTTIFREDI, VANESA; SORIA, GASTÓN

Deoxycytidine kinase (dCK) inhibition is synthetic lethal with BRCA2 deficiency

DRUG RESISTANCE UPDATES; Año: 2023 vol. 67

MANSILLA SF, BERTOLIN AP, VENERUS ARBILLA S, CASTAÑO BA, JAHJAH T, SINGH JK, SIRI SO, CASTRO MV, DE LA VEGA MB, QUINET A, WIESMÜLLER L, GOTTIFREDI V.

Polymerase iota prevents PrimPol-mediated nascent DNA synthesis and chromosome instability.

Science Advances; Año: 2023

LUIS CALZETTA, NICOLÁS; ALEJANDRA GONZÁLEZ BESTEIRO, MARINA; GOTTIFREDI, VANESA

PARP Activity Fine-tunes the DNA Replication Choreography of Chk1-depleted Cells

JOURNAL OF MOLECULAR BIOLOGY; Año: 2021 vol. 433

IHLE, MICHAELA; BIBER, STEPHANIE; SCHROEDER, INSA S; BLATTNER, CHRISTINE; DENIZ, MIRIAM; DAMIA, GIOVANNA; GOTTIFREDI, VANESA; WIESMULLER, LISA

Impact of the interplay between stemness features, p53 and pol iota on replication pathway choices

NUCLEIC ACIDS RESEARCH; Año: 2021 vol. 49 p. 7457 - 7475

SIRI, SEBASTIÁN OMAR; MARTINO, JULIETA; GOTTIFREDI, VANESA

Structural chromosome instability: Types, origins, consequences, and therapeutic opportunities

Cancers; Año: 2021 vol. 13

MANSILLA, SABRINA FLORENCIA; DE LA VEGA, MARÍA BELÉN; CALZETTA, NICOLÁS LUIS; SIRI, SEBASTIÁN OMAR; GOTTIFREDI, VANESA

CDK-Independent and PCNA-Dependent Functions of p21 in DNA Replication

Genes; Año: 2020 vol. 11

FEDERICO, MARÍA BELÉN; SIRI, SEBASTIÁN OMAR; CALZETTA, NICOLÁS LUIS; PAVIOLO, NATALIA SOLEDAD; DE LA VEGA, MARÍA BELÉN; MARTINO, JULIETA; CAMPANA, MARÍA CAROLINA; WIESMÜLLER, LISA; GOTTIFREDI, VANESA

Unscheduled MRE11 activity triggers cell death but not chromosome instability in polymerase eta-depleted cells subjected to UV irradiation

ONCOGENE; Año: 2020 vol. 39 p. 3952 - 3964

GOTTIFREDI, VANESA; WIESMÜLLER, LISA

Current Understanding of RAD52 Functions: Fundamental and Therapeutic Insights

Cancers; Año: 2020 vol. 12

BIBER, STEPHANIE; POSPIECH, HELMUT; GOTTIFREDI, VANESA; WIESMÜLLER, LISA

Multiple biochemical properties of the p53 molecule contribute to activation of polymerase iota-dependent DNA damage tolerance

NUCLEIC ACIDS RESEARCH; Año: 2020 vol. 48 p. 12188 - 12203

BERTOLIN, AGUSTINA P.; HOFFMANN, JEAN-SÉBASTIEN; GOTTIFREDI, VANESA

Under-Replicated DNA: The Byproduct of Large Genomes?

Cancers; Año: 2020 vol. 12

CALZETTA, NL, GONZÁLEZ BESTEIRO MA, GOTTIFREDI V

Mus81-Eme1?dependent aberrant processing ofDNA replication intermediates in mitosis impairs genome integrity

Science Advances; Año: 2020

GOTTIFREDI, VANESA

Targeting DNA damage response kinases in cancer therapy

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS; Año: 2020 vol. 821

VILLAFAÑEZ F, GARCÍA IA, CARBAJOSA S, PANSA MF, MANSILLA S, LLORENS MC, ANGIOLINI V, GUANTAY L, JACOBS H MADAUSS KP, GLOGER I, GOTTIFREDI V, BOCCO JL, SORIA G.

AKT inhibition impairs PCNA ubiquitylation and triggers synthetic lethality in homologous recombination-deficient cells submitted to replication stress.

ONCOGENE; Lugar: Londres; Año: 2019 vol. 38 p. 4310 - 4324

CARBAJOSA S, PANSA MF, ET AL AND GOTTIFREDI V (CORRESPONDING AUTHOR), SORIA G (CORRESPONDING AUTHOR)

Polo-like Kinase 1 Inhibition as a Therapeutic Approach to Selectively Target BRCA1-Deficient Cancer Cells by Synthetic Lethality Induction

CLINICAL CANCER RESEARCH; Lugar: Philadelphia; Año: 2019

VILLAFAÑEZ F, GARCÍA IA, CARBAJOSA S, PANSA MF, MANSILLA S, LLORENS MC, ANGIOLINI V, GUANTAY L, JACOBS H MADAUSS KP, GLOGER I, GOTTIFREDI V, BOCCO JL, SORIA G.

Development and Optimization of a Miniaturized Western Blot-Based Screening Platform to Identify Regulators of Post-Translational Modifications

High Throughput; Lugar: Basilea; Año: 2019 vol. 8

NATALIA SOLEDAD PAVIOLO, MARÍA BELÉN DE LA VEGA, MARÍA FLORENCIA PANSA, IRIS ALEJANDRA GARCÍA, NICOLÁS LUIS CALZETTA, GASTÓN SORIA (CORRESPONDING AUTHOR) AND VANESA GOTTIFREDI (CORRESPONDING AUTHOR)

Persistent double strand break accumulation does not precede cell death in an Olaparib-sensitive BRCA-deficient colorectal cancer cell model

GENETICS AND MOLECULAR BIOLOGY; Año: 2019

GONZÁLEZ BESTEIRO M , CALZETTA NL , LOUREIRO S, HABIF M, BÉTOUS R, PILLAIRE MJ, MAFFIA A , SABBIONEDA S , HOFFMANN JS AND GOTTIFREDI V.

Chk1 loss creates replication barriers that compromise cell survival independently of excess origin firing

EMBO JOURNAL; Lugar: Londres; Año: 2019

GONZÁLEZ BESTEIRO, MARINA ALEJANDRA; GOTTIFREDI, VANESA

ETAA1 ensures proper chromosome segregation: A matter of S phase or mitosis?

JOURNAL OF CELL BIOLOGY; Año: 2019 vol. 218 p. 3883 - 3884

FEDERICO MB1, CAMPODÓNICO P1, PAVIOLO NS1, GOTTIFREDI V2.

Beyond interstrand crosslinks repair: contribution of FANCD2 and other Fanconi Anemia proteins to the replication of DNA.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS; Lugar: Amsterdam; Año: 2018

GOTTIFREDI V.; WIESMULLER L

The Tip of an Iceberg: Replication-Associated Functions of the Tumor Suppressor p53.

Cancers; Lugar: Basilea; Año: 2018 vol. 10

GÜTTLEIN LN, BENEDETTI LG, FRESNO C, SPALLANZANI RG, MANSILLA SF, ROTONDARO C, RAFFO IRAOLAGOITIA XL, SALVATIERRA E, BRAVO AI, FERNÁNDEZ EA, GOTTIFREDI V, ZWIRNER NW, LLERA AS, PODHAJCER OL.

Predictive Outcomes for HER2-enriched Cancer Using Growth and Metastasis Signatures Driven By SPARC.

MOLECULAR CANCER; Lugar: Londres; Año: 2017 vol. 15 p. 304 - 316

LERNER LK, FRANCISCO G, SOLTYS DT, ROCHA CR, QUINET A, VESSONI AT, CASTRO LP, DAVID TI, BUSTOS SO, STRAUSS BE, GOTTIFREDI V, STARY A, SARASIN A, CHAMMAS R, MENCK CF.

Predominant role of DNA polymerase eta and p53-dependent translesion synthesis in the survival of ultraviolet-irradiated human cells.

NUCLEIC ACIDS RESEARCH; Año: 2017 vol. 45 p. 1270 - 1280

FENOY IM, BOGADO SS, CONTRERAS SM; GOTTIFREDI V.; ANGEL S

The Knowns Unknowns: Exploring the Homologous Recombination Repair Pathway in Toxoplasma gondii.

frontiers in microbiology; Año: 2016 vol. 7

S HAMPP, T KIESSLINGA, K BUECHLEA, S F. MANSILLAB, J THOMALEC, M RALLA, J AHN, H POSPIECHE, V GOTTIFREDI, AND LWIESMÜLLER

A DNA damage tolerance pathway involving DNA polymerase iota and the tumor suppressor p53 regulates DNA replication fork progression

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Año: 2016 vol. 113 p. 4311 - 4319

MB FEDERICO, MB VALLERGA, A RALD, NP PAVIOLO, JL BOCCO, M DI GIORGIO, G SORIA, GOTTIFREDI V.

Chromosomal Integrity after UV Irradiation requires FANCD2-mediated Repair of Double Strand Breaks.

PLOS GENETICS; Lugar: San Francisco; Año: 2016

MANSILLA SF, BETOLIN AP, BERGOGLIO V, PILLAIRE MJ, GONZALEZ M, LUZZANI C, MIRIUKA S, CAZAUX C, HOFFMANN JS, GOTTIFREDI V

Cyclin Kinase-independent role of p21CDKN1A in the promotion of nascent DNA elongation in unstressed cells

eLife; Lugar: Cambridge; Año: 2016

GONZALEZ BESTEIRO M, GOTTIFREDI V

The fork and the kinase: A DNA replication tale from a CHK1 perspective

MUTATION RESEARCH. REVIEWS IN MUTATION RESEARCH; Año: 2015 vol. 763 p. 168 - 180

BERTOLIN A, MANSILLA SF Y GOTTIFREDI V

The identification of translesion DNA synthesis regulators: inhibitors in the spotlight

DNA REPAIR; Lugar: Amsterdam; Año: 2015 vol. 32 p. 158 - 164

VALLERGA MB, MANSILLA SF, FEDERICO MB, BERTOLIN AP, GOTTIFREDI V

Rad51 prevents Mre11-dependent degradation and excessive primpol-mediated elongation of nascent DNA after UV irradiation

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Lugar: Washington DC, USA; Año: 2015 vol. 112 p. 6624 - 6633

QUINET A, VESSONI AT, ROCHA CR, GOTTIFREDI V, BIARD D, SARASIN A, MENCK CF, STARY A.

Gap-filling and bypass at the replication fork are both active mechanisms for tolerance of low-dose ultraviolet-induced DNA damage in the human genome.

DNA REPAIR; Lugar: Amsterdam; Año: 2014 vol. 14 p. 27 - 38

COSTANTINO V; MANSILLA SABRINA; SPERONI J; AMAYA C; CUELLO- CARIO, D; CIOCCA DR; PRIESTAP HA; BARBIERI MA, ; GOTTIFREDI V (CORRESPONDING AUTHOR); LOPEZ, LA (CORRESPONDING AUTHOR)

The sesquiterpene lactone dehydroleucodine triggers senescence and apoptosis in association with accumulation of DNA damage markers

PLOS ONE; Lugar: San Francisco; Año: 2013 vol. 8 p. 53168 - 53178

MANSILLA SF, SORIA G, VALLERGA MB, HABIF M, MARTÍNEZ-LÓPEZ W, PRIVES C, GOTTIFREDI V

UV-triggered p21 degradation facilitates damaged-DNA replication and preserves genomic stability.

NUCLEIC ACIDS RESEARCH; Lugar: Oxford; Año: 2013 vol. 41 p. 6942 - 6951

PODEROSO C; DUARTE A; COOKE M; ORLANDO U; GOTTIFREDI V; SOLANO AR; LEMOS JR; PODESTÁ EJ

The spatial and temporal regulation of the hormonal signal. Role of mitochondria in the formation of a protein complex required for the activation of cholesterol transport and steroids synthesis.

MOLECULAR AND CELLULAR ENDOCRINOLOGY.; Lugar: Amsterdam; Año: 2013 vol. 371 p. 26 - 33

DUARTE A, PODEROSO C, COOKE M, SORIA G, CORNEJO MACIEL F, GOTTIFREDI V, PODESTÁ EJ

Mitochondrial fusion is essential for steroid biosynthesis

PLOS ONE; Lugar: San Francisco; Año: 2012 vol. 7 p. 458 - 469

SPERONI J, FEDERICO B, MANSILLA S, SORIA G AND GOTTIFREDI V

A kinase independent role of Chk1 in the replication of damaged DNA

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Lugar: Washington DC, USA; Año: 2012 vol. 109 p. 7344 - 7349

THOMAS MG, LUCHELLI L, PASCUAL M, GOTTIFREDI V AND BOCCACCIO G

A monoclonal antibody against p53 cross-reacts with processing bodies

PLOS ONE; Lugar: San Francisco; Año: 2012 vol. 7 p. 36447 - 36456

SPERONI J AND GOTTIFREDI V

p21 regulates the cell cycle?or the other way around?

CELL CYCLE; Lugar: Austin, Texas; Año: 2011 vol. 10 p. 3430 - 3430

SORIA GASTON; GOTTIFREDI VANESA

PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule?

DNA REPAIR; Año: 2010 vol. 9 p. 358 - 364

AHN JINWOO; POYUROWSKY MASHA; BAPTISTE NICOLE; BECKERMAN RACHEL; CAIN CHRISTINE; MCKINNEY KRISTINE; ZHOU JIANMIN; ZUPNICK ANDREW; GOTTIFREDI VANESA; PRIVES CAROL

Dissection of the sequence-specific DNA binding and exonuclease activities reveals a superactive yet apoptotically impaired mutant p53 protein

CELL CYCLE; Año: 2009 vol. 8 p. 1603 - 1615

SORIA GASTON; BELLUSCIO LAURA; VAN CAPELLEN WA; KANAAR ROLAND; ESSERS JEROEN; GOTTIFREDI VANESA

DNA damage induced Pol eta recruitment takes place independently of the cell cycle phase.

CELL CYCLE; Año: 2009 vol. 8 p. 3340 - 3348

POLICASTRO LL, IBAÑEZ IL, DURÁN HA, SORIA G, GOTTIFREDI V, PODHAJCER OL.

Suppression of cancer growth by nonviral gene therapy based on a novel reactive oxygen species-responsive promoter.

MOLECULAR THERAPY (PRINT); Año: 2009 vol. 17 p. 1355 - 1364

SORIA GASTON; SPERONI JULIANA; PODHAJCER OSVALDO; PRIVES CAROL; GOTTIFREDI VANESA

p21 differentially regulates DNA replication and DNArepair-associated processes after UV irradiation

JOURNAL OF CELL SCIENCE; Año: 2008 vol. 121 p. 3271 - 3282

PRIVES CAROL; GOTTIFREDI VANESA

The p21 and PCNA partnership: a new twist for an old plot

CELL CYCLE; Año: 2008 vol. 7 p. 1 - 7

LÓPEZ HABER CYNTHIA* (COLABORACIÓN IGUALITARIA); GOTTIFREDI VANESA * (COLABORACIÓN IGUALITARIA); LLERA ANDREA S; SALVATIERRA EDGARDO; PRADA FEDERICO; ALONSO LEONARDO; SAGE HELENE; PODHAJCER OSVALDO

SPARC modulates the proliferation of stromal but not melanoma cells unless

INTERNATIONAL JOURNAL OF CANCER. JOURNAL INTERNATIONAL DU CANCER.; Año: 2008 p. 1465 - 1475

MATTIA M, GOTTIFREDI V, MCKINNEY K, PRIVES C

p53-Dependent p21 mRNA elongation is impaired when DNA replication is stalled

MOLECULAR AND CELLULAR BIOLOGY; Lugar: Washington, USA; Año: 2007 vol. 27 p. 1309 - 1320

SORIA GASTON, PODHAJCER OSVALDO, PRIVES CAROL, GOTTIFREDI VANESA

P21(Cip1/WAF1) downregulation is required for efficient PCNA ubiquitination after UV irradiation.

ONCOGENE; Lugar: Londres; Año: 2006 vol. 25 p. 2829 - 2838

GOTTIFREDI V, PRIVES C

The S phase checkpoint: when the crowd meets at the fork

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY; Lugar: Burlington; Año: 2005 vol. 16 p. 355 - 368

GOTTIFREDI V, MCKINNEY K, POYUROVSKY MV, PRIVES C

Decreased p21 levels are required for efficient restart of DNA synthesis after S phase block

JOURNAL OF BIOLOGICAL CHEMISTRY; Año: 2004 vol. 279 p. 5802 - 5810

MCKINNEY K, MATTIA M, GOTTIFREDI V, PRIVES C

p53 linear diffusion along DNA requires its C terminus

MOLECULAR CELL; Año: 2004 vol. 5 p. 413 - 424

GOTTIFREDI V, PRIVES C

Molecular biology. Getting p53 out of the nucleus

SCIENCE; Año: 2001 vol. 292 p. 1851 - 1852

GOTTIFREDI V, PRIVES C

P53 and PML: new partners in tumor suppression

TRENDS IN CELL BIOLOGY; Año: 2001 vol. 11 p. 184 - 187

GOTTIFREDI VANESA; KARNI SCHMIDT ORIT; SHIEH SHEAU YANN; PRIVES CAROL

p53 down-regulates CHK1 through p21 and the retinoblastoma protein

MOLECULAR AND CELLULAR BIOLOGY; Año: 2001 vol. 21 p. 1066 - 1076

GOTTIFREDI VANESA; SHIE SHEAY YANN; TAYA YOICHI; PRIVES CAROL

p53 accumulates but is functionally impaired when DNA synthesis is blocked

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Año: 2001 vol. 98 p. 1036 - 1041

PALKOVÁ Z, SPANIELOVÁ H, GOTTIFREDI V, HOLLANDEROVÁ D, FORSTOVÁ J, AMATI P

The polyomavirus major capsid protein VP1 interacts with the nuclear matrix regulatory protein YY1

FEBS LETTERS; Lugar: Amsterdam; Año: 2000 vol. 467 p. 359 - 364

GOTTIFREDI V, SHIEH SY, PRIVES C

Regulation of p53 after different forms of stress and at different cell cycle stages

Cold Spring Harbor Symposia on Quantitative Biology; Año: 2000 vol. 65 p. 483 - 488

GOTTIFREDI V, PELICCI G, MUNARRIZ E, MAIONE R, PELICCI PG, AMATI P.

Polyomavirus large T antigen induces alterations in cytoplasmic signalling pathways involving Shc activation.

JOURNAL OF VIROLOGY; Lugar: Washington; Año: 1999 vol. 73 p. 1427 - 1437

GOTTIFREDI V, PESCHIAROLI A, FIMIA GM, MAIONE R

p53-independent apoptosis induced by muscle differentiation stimuli in polyomavirus large T-expressing myoblasts

Journal Cell Science; Año: 1999 vol. 112 p. 2397 - 2407

FIMIA GM, GOTTIFREDI V, BELLEI B, RICCIARDI MR, TAFURI A, AMATI P, MAIONE R

The activity of differentiation factors induces apoptosis in polyomavirus large T-expressing myoblasts

MOLECULAR BIOLOGY OF THE CELL; Año: 1998 vol. 9 p. 1449 - 1463

FIMIA GM, GOTTIFREDI V, PASSANANTI C, MAIONE R

Double-stranded internucleosomal cleavage of apoptotic DNA is dependent on the degree of differentiation in muscle cells

JOURNAL OF BIOLOGICAL CHEMISTRY; Año: 1998 vol. 28 p. 15575 - 15579