Cell death in duodenal mucosa in celiac disease

RUERA CAROLINA; PEREZ F; GUZMAN L; MENENDEZ L; GARBI L; CHIRDO FG

Ayr, Escocia

Simposio; 32th Meeting of the European Group of Prolamin Analysis and Toxicity; 2018

European Group of Prolamin Analysis and Toxicity

Celiac disease (CD) is a multifactorial immune-mediated disease that develops in genetically susceptible individuals after ingestion of a group of proteins derived from wheat, barley and rye, commonly named gluten. CD is a chronic enteropathy characterised by severe changes in the histology of proximal small intestine mucosa. These changes include massive loss of enterocytes and villi, and crypt hyperplasia. The increased enterocyte death has been explained by an uncontrolled apoptosis induction due to excessive activation of intraepithelial lymphocytes (IELs). Apoptosis has been considered as the main pathway of enterocytes death, however this mechanism has been only partially studied.