Mechanisms of mucosal damage induced by p31-43 and poly I:C in murine small intestine

GOMEZ CASTRO M.F; ARAYA R; CARASI P; VERDU E; CHIRDO F

Vienna

Simposio; 29th Meeting of the European Prolamin Working Group of Prolamin Analysis and Toxicity; 2015

European Prolamin Working Group of Prolamin Analysis and Toxicity

Several studies have shown that a set of gluten-derived peptides are immunogenic and induce a potent gluten-specific CD4+ T cell response in the small intestinal mucosa in CD patients [1]. Particularly, transgutaminase 2 converts native into deamidated gluten peptides, which bind to HLA-DQ2 and DQ8 molecules with higher affinity enhancing T cell activation [2]. On the other hand, some gluten peptides may mediate non-HLA related effects, which could lead to innate immune activation [3]. However the signaling pathways of innate immune activation by gluten peptides remain unclear.The aim of this work was to evaluate the signaling pathways involved in the mechanisms of damaged elicited by gliadin p31-43