Superantigens of the egc operon: SEG, SEI, SEO and SEM differential effect on IL-6 signal transducer (gp130), IL17 release and γδT cells

NOLI TRUANT SOFÍA; SARRATEA MARÍA BELÉN; JANCIC, CAROLINA; IANNANTUONO LOPEZ, LAURA; ANTONOGLOU MARÍA BELÉN; FERNÁNDEZ MARISA M; REDOLFI DANIELA; MALCHIODI EMILIO L

Mar del Plata

Congreso; LXVI Reunión Anual de la SAI; 2018

Sociedad Argentina de Inmunología

Superantigens (SAgs) are enterotoxins that promote massive cytokine release and immunosuppression. Most of them are produced by extracellular bacteria, such as S. aureus and S. pyogenes. IL-17 is a crucial cytokine in the eradication of these pathogens. Here, we investigated the effect of four egc operon natural SAgs (SEG, SEI, SEO and SEM) on the innate immunity and its IL-17 arm.SAgs induce production of higher concentrations of IL-6 (ELISA) on PBMCs compared to control (p