Characterization of the intestinal mucosal immune response against the helminth Trichinella spiralis

SARACINO P; ROUX M ESTELA; VENTURIELLO, S.M.

Simposio; Cell Symposia multifacated type 2 immunity; 2014

The parasite disease caused by Trichinella spiralis induces a mucosal immune system response which leads to the rejection of adult worms from the intestine in Wistar rats (13 days post-infection, dpi). We characterized the kinetics of the appearance of immunological parameters involved in the development of an intestinal inflammatory process with an initial Th1 response during the first dpi (1-3) which then changes to a Th2 response (3-13 dpi). Intestinal villi hyperplasia, elevation of the levels of cytokines, chemokines, and total and specific immunoglobulins (IgA, IgE, IgG1, IgG2a) against each intestinal parasite stage (adult worm, muscle larvae and newborn larvae) in intestinal tissue extracts were observed. IgE+ cells and IgE levels were higher than those found in IgA. Simultaneously to this intestinal response, an inflammatory response in lung tissue is generated due to a co-stimulatory process between mucosae, inducing an efficient protection of the host.