ORAL DAILY MELATONIN SUPLEMENTATION ATTENUATES OXIDATIVE STRESS IN TESTES OF MEN WITH IDIOPATHIC INFERTILITY

PONZIO, R; MARTINEZ, G; MATZKIN ME; ROSSI, SP; LEVALLE, O; CALANDRA, RS; RIVIERE, E; PUIGDOMENECH, E; TERRADAS, C; FRUNGIERI, MB

MAR DEL PLATA

Congreso; LXIV Reunión Científica Anual de la Sociedad de Investigación Clínica (SAIC); 2019

Melatonin (mel) modulates testicular function acting indirectly through the hypothalamus/pituitary and directly on different gonadal cells. We previously demonstrated that testicular expression of several inflammatory markers increases in biopsies of infertile patients compared to biopsies of men with normal spermatogenesis. Oral mel intake attenuates testicular inflammation in infertile patients.Because inflammation and oxidative stress are co-dependent pathophysiological processes, and mel is known as a potent antioxidant agent, in this study we evaluated the impact of oral mel supplementation on testicular oxidative state in infertile patients.Testicular biopsies of patients with idiopathic infertility (n=35) and normal histology (n=6) were used. A sub-group of infertile patients (n=11) were under mel supplementation (3 mg single oral daily dose) to treat sleep disorders.Mel concentration was lower in testes of infertile patients compared to gonads of men with normal morphology. Oral daily mel intake in infertile patients restored testicular mel concentration close to control levels (p