NATIVE PLANTS AND NEUROPROTECTIVE EFFECTS IN DIABETES MELLITUS

REY, M.; TAPIA, A. J.; MAGRINI-HUAMÁN, R.N.; COIRINI, H.; KRUSE, M.S; FERESIN, G.E.

CABA

Congreso; SEGUNDAS JORNADAS RIOPLATENSES DE BIOLOGIA; 2018

SOCIEDAD ARGENTINA DE BIOLOGIA / SOCIEDAD URUGUAYA DE BIOCIENCIAS

In Cuyo region (Argentine) Tessaria absinthioides (Ta) and Oxalis erythrorhiza (Oe) are popularly consumed to regulate glucose (Glu) and cholesterol (Chol) levels, lacking of scientific support. Several works indicate that 85% of world population uses ?medicinal plants? to treat its health. Diabetes mellitus patients have chronic hyperglycemia, oxidative stress state and can also develop neurodegenerative changes. This is a problem for health systems, thus the search of alternative therapies remains in force. Previously, we had shown effects of Ta and Oe decoctions (10% W/V) on metabolism and LXRs expression in hypothalamus (HT). In this work, adult male rats (SD), controls (C, i.p.veh.) or diabetics (D, i.p. STZ 30 mg/Kg) drink decoctions (10% W/V) of Ta (CTa/DTa), Oe (COe/DOe) or water (CW/DW) by 4 weeks. Glu, Chol and triglycerides (Tg) levels were measured on blood samples by commercial kits. Neural NOS (nNOS) and Neurofilaments 200 (NF200, 3 different bands) expression levels were studied in HT by WB. Compared to CW, DW, DOe and DTa had higher Glu (350%, 200% and 200% resp.; p