Low level laser therapy (LLLT) reduces chemotherapy-induced ovarian damage

OUBIÑA G,; VELAZQUE C; PARBORELL F; L. SCOTTI; ABRAMOVICH DAHIA; N PASCUALI; NEGRI MONTES L

Jornada; XX Jornadas Anuales de la Sociedad Argentina de Biología (SAB) junto a la S; 2018

SAB

It is known that LLLT has beneficial effects on several processes including wound healing, pain and inflammation. LLLT modulates biological functions, including cell proliferation, apoptosis and angiogenesis, which in the ovary are intimately related to fertility. Premature Ovarian Failure (POF) is characterized by the disappearance of ovarian follicles in young women, which may be caused by chemotherapy. Current treatments for POF, mainly hormone therapies, are not completely effective. The present study proposes photobiomodulation as a strategy to protect the ovary in patients undergoing chemotherapy. Thein rat granulosa cells, MTS and Annexin assays were performed respectively. DX reduced viability compared to control (p