EFFECTIVENESS OF A MONOCLONAL ANTIBODY AGAINST HUMAN CHORIONIC GONADOTROPIN (hCG) TO PREVENT REPRODUCTIVE AND METABOLIC DYSFUNCTIONS IN TRANSGENIC FEMALE MICE

GUPTA J ; TALWAR GP; RATNER LD; CALANDRA RS ; MARCIAL LÓPEZ CA ; NAND K; RULLI SB

Geneva

Congreso; 33rd Annual Meeting of the European Society of Human Reproduction and Embryology; 2017

Human Reproduction

These results showed that the treatment was a useful strategy to normalize, at least in part, the phenotype of hCGβ+ females. The effectiveness of this treatment would depend on the stage at which it is administered. It was more effective in reversing the phenotype when administered to transgenic young females than at adulthood. It would be necessary to analyze other doses and administration schedules to normalize the phenotypic alterations that were resistant to the conditions used in this study.