CONICET | Buscador de Institutos y Recursos Humanos

After recognition, NK cells can kill susceptible target cells through perforin-dependent mech-Q2anisms or by inducing death receptor-mediated apoptosis, and they can also secrete cytokinesthat are pivotal for immunomodulation. Despite the critical role as effector cells against tumorsand virus-infected cells, NK cells have been implicated in the regulation of T cell-mediatedresponses in different models of autoimmunity, transplantation, and viral infections. Here, wereview the mechanisms described for NK cell-mediated inhibition of adaptive immune responses,with spotlight on the emerging evidence of their regulatory role that shapes antitumor immuneresponses.