Bone marrow/bone pre-metastatic niche for breast cancer cells colonization: The role of mesenchymal stromal cells

GIORELLO, M.B.; CHASSEING, N.A.; SANMARTIN, M.C.; PACIENZA, N.; BORZONE, F.R.; YANNARELLI, G.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

ELSEVIER SCIENCE INC

Lugar: Amsterdam; Año: 2021 vol. 164

1040-8428

Breast cancer is one of the most common oncological pathologies in women worldwide. While its early diagnosis has considerably improved, about 70 % of advanced patients develop bone metastases with a high mortality rate. Several authors demonstrated that primary breast cancer cells prepare their future metastatic niche –known as the pre-metastatic niche- to turn it into an “optimal soil” for colonization. The role of the different cellular components of the bone marrow/bone niche in bone metastasis has been well described. However, studying the changes that occur in this microenvironment before tumor cells arrival has become a novel research field. Therefore, the purpose of this review is to describe the current knowledge about the modulation of the normal bone marrow/bone niche by the primary breast tumor, in particular, highlighting the role of mesenchymal stem/stromal cells in transforming this soil into a pre-metastatic niche for breast cancer cells colonization.