IN VITRO AND IN VIVO SYNERGISTIC ANTITUMOR EFFECT OF THAPSIGARGIN AND A PENICILLIN DERIVATIVE IN MURINE MELANOMA CELLS

DELPICCOLO, CARINA; BOGGIAN BIBIANA; ROGUIN LEONOR; BELLIZZI YANINA; CAYROL MARIA F; MATA ERNESTO G; CORNIER PATRICIA; CREMASCHI, GRACIELA A; BLANK VIVIANA

Mar del Plata

Congreso; Reunión Conjunta SAIC-SAFE-SAB-SAP; 2019

SAIC-SAFE-SAB-SAP

The triazolyl peptidyl penicillins (TAPs) arenovel hybrids compounds having in their structure a penicillaniccore linked to a peptide portion via a triazole group. In aprevious study, we showed that the derivative containing thedipeptide Leu-Phe (TAP7f) activates an endoplamic reticulum(ER) stress response and induces apoptosis of murine B16-F0melanoma cells. In this work, we first demonstrated thecontribution of ER stress to the antitumor effect of TAP7f. Whencell viability was determined after pre-incubating cells with aspecific siRNA for CHOP, a protein involved in ER stress signaling,cell growth increased from 25 ± 2% to 40 ± 1% (p