EFFECTS OF FLAXSEED OIL RICH IN LIGNANS ON LIPID ALTERATIONS INDUCED BY CAFETERIA DIET IN RATS

FARIÑA, ANA CLARA; LAVANDERA, JIMENA; VERA CANDIOTI, LUCIANA; BERNAL, CLAUDIO

Virtual

Congreso; LXVI REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INVESTIGACIÓN CLÍNICA (SAIC); 2021

SAIC-SAI-SAFIS

Cafeteria (CAF) diet, composed by palatable foods high in saturated fat and refined carbohydrates, leads to a deregulation of lipid metabolism with hepatic triacylglycerol (TAG) accumulation which can progress to non-alcoholic fatty liver disease (NAFLD). Flaxseed oil (FO) can be used as a functional food ingredient due to its potential health benefits and excellent nutrient profile. The principal component of virgin FO is α-linolenic acid, which can be enriched with lignans (LGN). This preliminary study aimed to investigate the effects of virgin FO rich in LGN on the alterations induced by the cafeteria diet. Wistar rats (310g) were fed during 60 days with the diets: control (SO): soybean oil 4%, CAF (C): lipids 30% and CAF+FO (CF): lipids 26%+4% FO rich in LGN. Food intake, body weight gain, relative epididymal (EAT) and retroperitoneal (RPAT) adipose tissues and liver weights; and serum TAG, cholesterol (CHO) and glucose (GLU) levels, were measured. Liver fatty acids profile was determinate by gas chromatography. Data were analyzed by One-Way ANOVA followed by Tukey´s test (p