Lactobacillus rhamnosus RC007 with immune-modulatory properties in an experimental model of TNBS-induced colitis in mice. Potential use as a feed additive for pig production

GARCÍA, G; DOGI C.A; DE MORENO DE LEBLANC A; CAVAGLIERI L.R.; GRECO C.

Congreso; 11 Congress of the latin American Association of Immunology-ALAI 10 Colombian Congress of Allergy, Asthma and Immunology. ACAAI; 2015

In piglets inflammatory processes take place at intestinal level as consequence of weaning, inducing significant changes in gut anatomy, the immune function and consequently, the productivity indexes. Antibiotics have been banned as growth promoters in animal feed. Different alternatives, such as probiotics have been explored and represent a potentially significant therapeutic or preventive safe advance in animal production. The aim of this work was to evaluate the immunomodulatory effect of Lactobacillus rhamnosus RC007 in an experimental model of TNBS-induced colitis in mice. The trial was conducted to test the ability of LAB to attenuate the inflammatory effects that occur in the post weaning period and use it as a food additive in pig production. Less macroscopic and histological damages in the large intestine were accompanied by increased IL-10/TNFα ratio in the intestinal fluids of mice from L. rhamnosus-TNBS group when compared to TNBS group. L. rhamnosus RC007 is a potential probiotic bacterium that can provide therapeutic benefits to infected/inflamed animals.