INVESTIGADORES
FERNANDEZ Juan Manuel
congresos y reuniones científicas
Título:
Polymeric And Strontium Composite Based Scaffold For Bone Tissue Engineering
Autor/es:
LINO A; TORRES ML; MCCARTHY AD; FERNANDEZ JM
Reunión:
Workshop; II Workshop on Bio-degradable Polymers and Biocomposites and III Workshop BIOPURFIL, Bio-based Polyurethane Composites with Natural Fillers; 2015
Resumen:
Bone tissue engineering (BTE) uses different materials to design scaffolds that guide bone regeneration. In our group we have developed various polymers for application in BTE. One of these is a compatibilized blend of a polyester (poly-ε-caprolactone, PCL) and a polyfumarate (poly diisopropyl fumarate, PDIPF). This blend shows better osteocompatibility for cultured bone marrow progenitor cells (BMPC) than the respective homopolymers, in addition to no toxicity [1]. Strontium ranelate is a drug with dual anti-catabolic and anabolic action on bone metabolism, and is used for treatment of osteoporosis. We have previously loaded the compatibilized blend with 1% and 5% of Sr+2, and found that it does not release significant amounts of Sr+2 into the culture medium. However, the scaffold with 1% Sr+2 increased phosphatase alkaline activity (ALP) of BMPC cultures, while 5% Sr+2 decreased their ALP [2]. The objective of this study was to evaluate if the Sr+2-loaded polymer induces similar effects on BMPC type 1 collagen production, as well as its possible cytotoxicity (NO and LDH release).