Gut borne Saccharomyces cerevisiae, a promising candidate for the formulation of feed additives, modulates immune system and gut microbiota

GARCÍA, G; DOGI C.A; DE MORENO DE LEBLANC A; GRECO C.; CAVAGLIERI L.R.

Beneficial microbes

Wagenigen Academic

Año: 2016 vol. 7 p. 659 - 668

1876-2883

The aim was to evaluate the effect of Saccharomyces cerevisiae RC016 on immune parameters and gut microbiota in healthy mice. Animals received S. cerevisiae RC016 during 10 days. Microbial translocation to liver and changes in some bacterial populations in cecum were determined. Immune stimulation was evaluated at gut level (measure of IgA+ cells and luminal cytokine profile) and by evaluating the activity of peritoneal macrophages. Oral administration of S. cerevisiae RC016 did not induce microbial traslocation to liver. Mice that received yeast increased the number of IgA+ cells in their intestines, the phagocytic activity of peritoneal macrophage and decreased TNFα levels in the small intestine with increases of IL-10/TNFα ratio. Administration of S. cerevisieae RC016 caused the decline of a logarithmic unit for enterobacteria counts compared to the control. The immune and gut microbiota modulation observed demonstrate that S. cerevisiae RC016 is a promising candidate for the formulation of feed additives to improve animal productivity. The beneficial in vivo effects observed for the potential probiotic S. cerevisiae RC016 with previously reported mycotoxin-binding properties, demonstrated that this strain could be suitable to be included in a novel product to improve animal productivity, with both probiotic and mycotoxin-binding properties; however studies in the specific host should be necessary to confirm this potential