INVESTIGADORES
PODESTA Ernesto Jorge
artículos
Título:
Tyrosine phosphatases in steroidogenic cells: regulation and function
Autor/es:
A. GOROSTIZAGA; F. CORNEJO MACIEL; L. BRION; P. MALOBERTI; E.J. PODESTÁ; C. PAZ
Revista:
MOLECULAR AND CELLULAR ENDOCRINOLOGY.
Editorial:
Elsevier Ltd.
Referencias:
Año: 2007 vol. 265 p. 131 - 137
ISSN:
0303-7207
Resumen:
In adrenocortical and Leydig cells PKA activation by trophic hormones increases the activity of protein tyrosine phosphatases and also induces the expression of MAP kinase phosphatase 1 (MKP-1), a dual activity protein phosphatase (serine/threonine and tyrosine). This work summarizes the knowledge on the regulation and the role played by cAMP-activated tyrosine phosphatases as well as MKP-1 in the hormonal activation of the acute and chronic phases of steroidogenesis.
