A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases.

HUNT MC; YAMADA J; MALTAIS LJ; WRIGHT M; PODESTA EJ; ALEXSON SE

JLR PAPERS IN PRESS

American Societies for Biochemistry and Molecular Biology

Lugar: United States; Año: 2005 vol. 46 p. 2029 - 2032

0022-2275

Acyl-CoA thioesterases, also known as acyl-CoA hydrolases, are a group of enzymes that hydrolyze CoA esters such as acyl-CoAs (saturated, unsaturated, branched-chain), bile acid-CoAs, CoA esters of prostaglandins, etc., to the corresponding free acid and CoA. However, there is significant confusion regarding the nomenclature of these genes. In agreement with the HUGO Gene Nomenclature Committee and the Mouse Genomic Nomenclature Committee, a revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases has been suggested for the 12 member family. The family root symbol is ACOT, with human genes named ACOT1-ACOT12, and rat and mouse genes named Acot1-Acot12. Several of the ACOT genes are the result of splicing events, and these splice variants are cataloged.