Immunomodulating capacity of exogenous and indigenous lactobacilli

DOGI, C.A.; MEDICI M; CG VINDEROLA; G PERDIGÓN

BIOCELL

Año: 2004 vol. 28 p. 67 - 67

0327-9545

Lactic acid bacteria (LAB) can modulate intestinal immune system when they come into contact as bacterial antigens with lymphoid cells of the gut. Aims: to investigate whether differences exist in the immunomodulating capacities of exogenous (EX) and indigenous (IN) LAB, respect to BALB/c mice, and to relate this with their cell-wall protein profiles. Methodology: sites of interaction in the gut and cell-wall profiles were determined for EX (L. acidophilus A9 and L L. casei A13) and IN (L. fermentum CRL 1386) strins. Number of IgA+, TNFa+, IFNg+, IL-2+, IL-4+ and IL-10+ cells were determined after oral administration of EX (107 cells/day) and IN (104 cells/ day) for 5 consecutive days. Results: a significant increase in the number of IgA+ cells in small and large intestine were observed following the oral administration of EX La A9, the IN strain Lf CRL 1386 increased the number of IgA+ cells in small intestine but lowered it in the large intestine. Only the EX strains were able to significantly increase the number of TNFa+ cells in the small intestine. La A9 significantly increased the number of IL-10+ cells in the small and large intestine. Conclusion: the immunomodulation capacity of LAB is independent of the host specificity but an exclusive property of the strain itself.