INVESTIGADORES
PIROLA Carlos Jose
artículos
Título:
Liver enzymes, metabolomics and genome-wide association studies: From systems biology to the personalized medicine.
Autor/es:
SILVIA SOOKOIAN; CARLOS J. PIROLA
Revista:
WORLD JOURNAL OF GASTROENTEROLOGY
Editorial:
W J G PRESS
Referencias:
Lugar: Beijing; Año: 2015 vol. 21 p. 711 - 725
ISSN:
1007-9327
Resumen:
For several decades, serum levels of alanine (ALT)
and aspartate (AST) aminotransferases have been
regarded as markers of liver injury, including a wide
range of etiologies from viral hepatitis to fatty liver.
The increasing worldwide prevalence of metabolic
and aspartate (AST) aminotransferases have been
regarded as markers of liver injury, including a wide
range of etiologies from viral hepatitis to fatty liver.
The increasing worldwide prevalence of metabolic
ral decades, serum levels of alanine (ALT)
and aspartate (AST) aminotransferases have been
regarded as markers of liver injury, including a wide
range of etiologies from viral hepatitis to fatty liver.
The increasing worldwide prevalence of metabolic
syndrome and cardiovascular disease revealed that
transaminases are strong predictors of type 2 diabetes,
coronary heart disease, atherothrombotic risk profile,
and overall risk of metabolic disease. Therefore, it
is plausible to suggest that aminotransferases are
surrogate biomarkers of ?liver metabolic functioning?
beyond the classical concept of liver cellular damage,
as their enzymatic activity might actually reflect
key aspects of the physiology and pathophysiology
of the liver function. In this study, we summarize
the background information and recent findings on
the biological role of ALT and AST, and review the
knowledge gained from the application of genome-wide
approaches and ?omics? technologies that uncovered
new concepts on the role of aminotransferases in
human diseases and systemic regulation of metabolic
functions. Prediction of biomolecular interactions
between the candidate genes recently discovered
to be associated with plasma concentrations of liver
enzymes showed interesting interconnectivity nodes,
which suggest that regulation of aminotransferase
activity is a complex and highly regulated trait. Finally,
links between aminotransferase genes and metabolites
are explored to understand the genetic contributions
to the metabolic diversity.