Personalizing care for nonalcoholic fatty liver disease patients: what are the research priorities?.

SILVIA SOOKOIAN; CARLOS JOSE PIROLA

PERSONALIZED MEDICINE

FUTURE MEDICINE LTD

Lugar: Londres; Año: 2014 vol. 11 p. 735 - 743

1741-0541

      Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease whose prevalence has reached global epidemic proportions, not only in adults but also in children. From a clinical point of view, NAFLD stems a myriad of challenges to physicians, researchers and patients. In this study, we revise the current knowledge and recent insights on NAFLD pathogenesis and diagnosis in the context of a personalized perspective with special focus on the following issues: noninvasive biomarkers for the evaluation of disease severity and progression, lifestyle-related patients? recommendations, risk prediction of disease by genetic testing, management of NAFLD-associated comorbidities and patient-oriented therapeutic intervention strategies.