INVESTIGADORES
PIROLA Carlos Jose
artículos
Título:
Epigenetics of Insulin Resistance: An Emerging Field in Translational Medicine
Autor/es:
SILVIA SOOKOIAN; CARLOS J. PIROLA
Revista:
CURRENT DIABETES REPORTS
Editorial:
CURRENT MEDICINE GROUP
Referencias:
Lugar: Philadelphia ; Año: 2013 vol. 13 p. 229 - 237
ISSN:
1534-4827
Resumen:
Abstract In this article, we review the current knowledge of and recent insights into the role of epigenetic factors in the development of insulin resistance (IR), with emphasis on peroxisome proliferator-activated receptor gamma coactivator 1α (PPARGC1A or PGC1α) methylation on fetal programming and liver modulation of glucose-related phenotypes.We discuss the pathogenesis of IR beyond the integrity of β-cell function and illustrate the novel concept of mitochondrial epigenetics to explain the pathobiology of metabolicsyndrome- related phenotypes. Moreover, we discuss whether epigenetic marks in genes of the circadian rhythm system are able to modulate insulin/glucose-related metabolic functions and place hypoxia inducible factor 1 α (HIF1α) as a part of the master CLOCK gene/protein interaction network that might modulate IR. Finally, we highlight relevant information about epigenetic marks and IR so that clinicians practicing in the community may envision future areas of medical intervention and predict putative biomarkers for early disease detection.