INVESTIGADORES
PIROLA Carlos Jose
artículos
Título:
Epigenetics of Insulin Resistance: An Emerging Field in Translational Medicine
Autor/es:
SILVIA SOOKOIAN; CARLOS J. PIROLA
Revista:
CURRENT DIABETES REPORTS
Editorial:
CURRENT MEDICINE GROUP
Referencias:
Lugar: Philadelphia ; Año: 2013 vol. 13 p. 229 - 237
ISSN:
1534-4827
Resumen:
Abstract In this article, we review the current knowledge
of and recent insights into the role of epigenetic factors in
the development of insulin resistance (IR), with emphasis on
peroxisome proliferator-activated receptor gamma coactivator
1α (PPARGC1A or PGC1α) methylation on fetal programming
and liver modulation of glucose-related phenotypes.We
discuss the pathogenesis of IR beyond the integrity of β-cell
function and illustrate the novel concept of mitochondrial
epigenetics to explain the pathobiology of metabolicsyndrome-
related phenotypes. Moreover, we discuss whether
epigenetic marks in genes of the circadian rhythm system are
able to modulate insulin/glucose-related metabolic functions
and place hypoxia inducible factor 1 α (HIF1α) as a part of
the master CLOCK gene/protein interaction network that
might modulate IR. Finally, we highlight relevant information
about epigenetic marks and IR so that clinicians practicing in
the community may envision future areas of medical intervention
and predict putative biomarkers for early disease
detection.