Maternal high-fat intake during pregnancy programs metabolic-syndrome-related phenotypes through liver mitochondrial DNA copy number and transcriptional activity of liver PPARGC1A.

BURGUENO, ADRIANA L; CABRERIZO, R; GONZALES MANSILLA N; SOOKOIAN, S.; PIROLA, CJ,

JOURNAL OF NUTRITIONAL BIOCHEMISTRY

ELSEVIER SCIENCE INC

Lugar: Amsterdam; Año: 2013 vol. 24 p. 6 - 14

0955-2863

In this study we contrasted the hypothesis that maternal diet during pregnancy has an impact on fetal metabolic programming through changes in liver mitochondrial DNA (mtDNA) content and transcriptional activity of Ppargc1a, and that these effects are sex specific. Methods: Rats were fed either high-fat (HFD) or standard chow diet (SCD) during gestation and lactation. The resulting adult male and female offspring were fed either HFD or SCD for an 18-week period, generating 8 experimental groups. Results: Maternal HFD feeding during pregnancy is associated with a decreased liver mtDNA copy number (p