INVESTIGADORES
PIROLA Carlos Jose
artículos
Título:
Thyrotropin-releasing hormone in cardiovascular pathophysiology.
Autor/es:
GARCIA SI; PIROLA CJ
Revista:
REGULATORY PEPTIDES
Editorial:
Elsevier/north Holland
Referencias:
Lugar: Netherlands; Año: 2005 vol. 30 p. 239 - 246
ISSN:
0167-0115
Resumen:
Thyrotropin (TSH)-releasing hormone (TRH) also known as thyroliberin was the first of a number of peptides exerting several roles as a hormone and as a neuropeptide. Its ubiquitous distribution in the hypothalamus and in the extrahypothalamic regions and its diverse pharmacological and physiological effects are all features of its dual functions. For this reason, TRH has been the subject of much research throughout the past 20 years, work that has examined the structure, function, distribution, and regulation of the tripeptide and it has been extensively reviewed elsewhere [O´Leary R., O´Connor B. Thyrotropin-releasing hormone. J Neurochem. 1995;65:953-963.; Nillni E., Sevarino K. The biology of pro-thyrotropin-releasing hormone-derived peptides. Endocrine Reviews, 1999;20:599-664.]. After a brief overview of its distribution, hypothalamic and extrahypothalamic functions, and receptors involved, this review discusses efforts devoted to support TRH role in cardiovascular regulation with a main focus on hypertension pathophysiology in experimental models and humans.