INVESTIGADORES
GENOVESE Diego Bautista
artículos
Título:
Studies of Pilocarpine:Carbomer Intermolecular Interactions.
Autor/es:
ZOPPI, ARIANA; GARRO LINCK, YAMILA; MONTI, GUSTAVO; GENOVESE, DIEGO B.; JIMENEZ KAIRUZ, ÁLVARO; MANZO, RUBEN; LONGHI, MARCELA
Revista:
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Año: 2012 vol. 427 p. 252 - 259
ISSN:
0378-5173
Resumen:
The
interactions between pilocarpine (PIL) and the anionic polyelectrolyte carbomer
(CBR) were investigated. The effects of the chemical interactions on the
chemical stability of the drug also were evaluated. The binary system was
characterized by nuclear magnetic resonance techniques, fourier-transform
infrared spectroscopy, X-ray powder diffraction, scanning electron microscopy
and thermal analysis. The experiments showed that the complex, prepared by
freeze-drying, is a solid amorphous form different from its precursors, thereby
offering an interesting alternative for the preparation of extended release
matrices. The solution stability of PIL was studied at pH 7 and 8, at 70 ºC.
The PIL solution stability was evaluated alone and in the presence of CBR.
Results indicated that the drug in the presence of the polymer is 3.3 and 3.5
times more stable, at pH 7 and pH 8,
respectively, than the drug without CBR. The activation energy and the
frequency factor, according to Arrhenius plot, were estimated to be 13.9 ± 0.4
and 14.8 ± 0.5 kcal mol−1, and 6.1 ± 0.3 and 7.6 ± 0.3, with and
without the polymer, respectively.