INVESTIGADORES
PIROLA Carlos Jose
artículos
Título:
SARS-CoV-2 targets the liver and manipulates glucose metabolism
Autor/es:
PIROLA, CARLOS J.; SOOKOIAN, SILVIA
Revista:
TRENDS IN MOLECULAR MEDICINE
Editorial:
ELSEVIER SCI LTD
Referencias:
Año: 2023 vol. 29 p. 681 - 683
ISSN:
1471-4914
Resumen:
A recent publication by Barreto and colleagues showed that SARS-CoV-2 directly triggers hyperglycemia by infecting hepatocytes and inducing phosphoenolpyruvate carboxykinase (PEPCK)-dependent gluconeogenesis. Here, we discuss the biological importance of these findings, including the hepatic tropism of SARS-CoV-2. We also comment on the clinical implications of the bidirectional connection between COVID-19 and noncommunicable diseases.
