Effect of conjugated linoleic acids on nutritional status and lipid metabolism in rats fed linoleic acid-enriched and -deprived diets

FARIÑA, ANA; LAVANDERA, JIMENA; GONZALEZ, MARCELA; BERNAL, CLAUDIO

EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY

WILEY-V C H VERLAG GMBH

Lugar: Weinheim; Año: 2019

1438-7697

This study aimed to investigate the differential effect of conjugated linoleic acid (CLA) on nutritional parameters, serum and tissue triacylglycerol (TAG) levels and the mechanisms involved in the TAG regulation in male Wistar rats fed LA-enriched (+LA) or LA-deprived ( LA) diets. In both, +LA and LA groups, CLA were incorporated into the tissues, showing higher levels in adipose tissue. However, different metabolic and nutritional effects were observed depending on the LA status. CLA markedly reduced fat depots in the -LA group, associated to an increased lipoprotein lipase (LPL) and lipogenic enzyme activities as compensatory mechanisms. Moreover, CLA restored the hepatic TAG levels in LA animals, associated to a normalized triacylglycerol-secretion rate (TAG-SR) and increased lipogenic enzyme activities. Serum TAG levels were not affected by CLA in the +LA group. However, in the -LA group, CLA decreased the TAG levels associated to a reduced TAG-SR and a higher adipose tissue LPL activity. Thus, the CLA effects on nutritional parameters and TAG metabolism differed depending on the LA status. CLA caused certain beneficial biological and nutritional effects in LA-deprived but not LA-enriched animals.