Maternal conjugated linoleic acid modulates triacylglyceride metabolism in adult rat offspring

LAVANDERA, JIMENA; GERSTNER, CAROLINA; SAIN, JULIANA; FARIÑA, ANA; GONZALEZ, MARCELA; BERNAL, CLAUDIO

BRITISH JOURNAL OF NUTRITION

CAMBRIDGE UNIV PRESS

Lugar: Cambridge; Año: 2017 vol. 118 p. 906 - 913

0007-1145

Conjugated linoleic acid (CLA) mightregulate the lipid depots in liver and adipose tissue. Since there is anassociation between maternal nutrition, fat depots and risk of offspringchronic disease, the aim of this study was to investigate theeffect of maternal CLA consumption on triacylglycerol (TAG) regulation and some inflammatoryparameters inadult male rat offspring receiving or not receiving CLA. Female Wistar rats were fed control(C) or CLA-supplemented (1%, w/w) diets during 4 weeks before and throughoutpregnancy and lactation. After weaning, male offspring of CLA rats were fed Cor CLA diets (CLA/C and CLA/CLA groups, respectively), while C male rat offspringwere fed a C diet (C/C group) for 9 weeks. Serum TAG levels were increased in the CLA/CLA and CLA/C groups,associated with a reduction of LPL activity and weights of adipose tissue. Theliver TAG levels were decreased in the CLA/CLA group, related to a significant reduction of FAS,ACC and G6PDH enzyme activities, as well as to the mRNA levels of FAS, ACC, SCD-1and SREBP-1c. Even though normal TAG levels were found in the liver ofCLA/C rats, a reduction of lipogenesis was also observed. Thus, these resultsdemonstrated a programming effect of CLA on the lipid metabolic pathways leading to apreventive effect on the TAG accretion in adipose tissue and the liver of male rat offspring. Thisknowledge could be important to develop some dietary strategies leading to a reducedincidence of obesity and fatty acid liver disease in humans.