Trans fatty acid retention and conversion rates of fatty acids in tissues depend on dietary fat in mice.

SAIN, JULIANA; GONZALEZ, MARCELA; LAVANDERA, JIMENA; SCALERANDI, MV; BERNAL, CLAUDIO

EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY

WILEY-V C H VERLAG GMBH

Lugar: Weinheim; Año: 2015 vol. 117 p. 1146 - 1158

1438-7697

Given that the effects of trans fatty acids (TFA) may be associated with the type of TFA isomerand the proportion of n-3/n-6/n-9 fatty acids (FA), this work aimed to investigate the influence ofdifferent oils on the following parameters: content, incorporation, and retention of TFA;conversion of vaccenic acid (VA) to rumenic acid (RA) in different tissues; and hepatic outputof TFA by VLDL. Another objective was to assess relative conversion rates of key FA andthe potential alteration of FA composition induced by TFA in tissues. Male CF1 mice were fed(30-days) diets containing 7% olive, corn or rapeseed oils either supplemented with 0.75% ofTFA or without added TFA. FA composition of liver, epididymal adipose tissue, gastrocnemiusmuscle, brain, and serum was assessed. With the exception of the brain, TFAs were incorporatedinto the analyzed tissues and serum. TFA retention and RA bioconversion from VA depended onthe dietary unsaturated FA proportions. The higher levels of hepatic RA in the liver of mice fedan olive oil.TFA diet could be associated with a raised D9-desaturase index. The FAcomposition of tissues was scarcely modified by the consumption of partially hydrogenatedvegetable oils containing similar proportions of t9-, t10-, and t11-18:1.