Peroxisome Proliferator-Activated Receptor Gamma (Pparg) And Its Coactivator-1 Alpha (Pgc-1a) May Be Associated With Features Of The Metabolic Syndrome In Adolescents.

SOOKOIAN, S.; GARCIA, S.; PORTO, P.; DIEUZEIDE, G.; GONZALEZ, CLAUDIO; CARLOS JOSE PIROLA

J Mol Endocrinol

ELSEVIER

Año: 2005 vol. 35 p. 375 - 382

0952-5041

Objective: to search for differences in genotypes of peroxisome proliferator-activated receptor gamma PPARg (Pro12Ala) and it?s coactivator PGC-1a (Gly482Ser) in adolescents harboring features of metabolic syndrome. Study design: in a population-based study, we determined medical history, anthropometrics variables, biochemical measurements and arterial blood pressures of 934 high school students of Caucasian origin, out of whom we selected 175. Results: we found no association between insulin resistance, BMI, and leptin levels and PPAR-g and PGC-1a genotypes. The 12Ala PPARg allele was associated with increased WHR and carriers seem to have higher diastolic blood pressure and lower pulse pressure than non-carriers, particularly in the overweight group. Despite of Ser482Ser PGC-1a homozygotes had lower WHR than other PGC-1a genotypes, they were more frequent in the hypertensive group than in normotensive one (44.4 % vs 24.5 %, p< 0.03), then the 482Ser PGC-1 allele was in our population, a risk factor for hypertension independently of WHR, HOMA, BMI and Pro12Ala PPAR-g variant (OR 4.0, 95% CL: 1.5-10.6, p<0.01). Multiple regression analysis showed that age and sex-adjusted systolic blood pressure correlated with the 482Ser PGC-1 allele regardless of those covariates. Conclusions: Gly482Ser variant of the PGC-1a gene may be an independent genetic risk factor for young-onset hypertension.