Phytotherapics with antibiotic activity on Streptococcus pneumoniae multi-resistant

ZAMPINI I. CATIANA, ,; ARIAS MYRIAM; CUDMANI NORMA; ISLA MARÍA INÉS.

Tafí del Valle - Tucumán

Jornada; Jornadas de Biología; 2006

Streptococcus pneumoniae is responsible for affections such as otitis, acute sinusitis, neumonía and meningitis. Although S. pneumoniae has been sensible to numerous antibiotics, in the last years have been appearing antibiotic-resistant S. pneumoniae strains. In Argentina approximately, the 36% of the clinical isolation are antibiotic-resistant.  The objective of the present work was to determine the sensitivity to commercial antibiotics and natural products of ten S. pneumoniae strains isolated of clinical samples obtained in a hospital of San Miguel de Tucumán. The minimal inhibitory concentration was determined by agar macrodilution assays. According with our results, 40% of the isolations were resistant to oxacillin, tetracicline and Trimetropime/sulphametoxazol and sensible to Levofloxacime, Eritromicin, Rifampicin, Clindamicin, Penicillin and Cefotaxime. The 100% of the isolations were sensible to Baccharis incarum, Baccharis boliviensis, Chuquiraga atacamensis and Parastrephia lucida extracts. The MIC values were 10 to 40 µg/ml for  Baccharis extracts and 20 to 80 µg/ml for the other plant species. In previous works we demonstrated that these phytotherapic also present antibiotic activity on other multi-resistant pathogenic human bacteria (Gram positive and Gram negative) and they act as free radical scavenging. Consequently these plant extracts could be used as antibiotic of topical use, to prevent states of oxidative stress and for the treatment of respiratory affections.