INVESTIGADORES
MAZZOLINI RIZZO Guillermo Daniel
artículos
Título:
Cytokine gene transfer for cancer therapy.
Autor/es:
OSVALDO L. PODHAJCER, MARÝA VERONICA LOPEZ, GUILLERMO MAZZOLINI
Revista:
CYTOKINE & GROWTH FACTOR REVIEWS
Editorial:
Elsevier
Referencias:
Año: 2007 vol. 18 p. 183 - 194
ISSN:
1359-6101
Resumen:
The possibility of inducing a strong immune response to impair tumor growth by ectopically expressing cytokines, followed by thegeneration of an antitumor memory raised great hopes and enthusiasm as a therapeutic approach. However, the efficacy of this strategy onestablished tumor models appeared low and the initial results in the clinics were disappointing. Recently, new evidence indicates that cytokinegene combination or the combined use of cytokine genes with additional gene therapy approaches induces a synergistic effect supporting theuse of cytokine gene therapy to improve the clinical outcome for cancer patients.
