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congresos y reuniones científicas
Título:
SPHINGOSINE-1-PHOSPHATE MANTAINS TISSUE HOMEOSTASIS IN DIFFERENTIATED EPITHELIAL CELLS
Autor/es:
SANTACREU BJ; UDOVIN LD; FAVALE NO; STERIN DE SPEZIALE NB
Lugar:
Iguazú
Reunión:
Congreso; 56th international conference of the Bioscience of lipids (ICBL); 2015
Institución organizadora:
Universidad nacional de córdoba, universidad nacional de quilmes
Resumen:
Sphingosine-1-phosphate is a sphingolipid mediator involved in cellular fate that acts both extracellularly as ligand for cell surface receptors (S1PR) and intracellularly as second messenger. We have demonstrated that hipertonicity induces epithelial cell differentiation wich depends on changes in sphingolipid metabolism. Ephitelial cell differentiation requires a specific intracellular organization as well as the correct monolayer formation.
