Vascular dysfunction elicited by a cross talk between periaortic adipose tissue and the vascular wall is reversed by pioglitazone

QUESADA, ISABEL; CEJAS, JIMENA; GARCÍA, RODRIGO; CANNIZZO, BEATRIZ; REDONDO, ANALÍA; CASTRO, CLAUDIA

CARDIOVASCULAR THERAPEUTICS

WILEY-BLACKWELL PUBLISHING, INC

Año: 2018

1755-5914

Perivascular adipose tissue (PVAT) is in intimate contact with the vessel wall and extravascular PVAT‐derived inflammatory mediators may adversely influence atherosclerotic plaque formation and stability through outside‐to‐inside signaling. We sought to investigate the role of PVAT on the atheroma development in an experimental animal model of metabolic syndrome (MS) associated with oxidative stress and low‐grade inflammatory state. We also studied the effect of pioglitazone an insulin sensitizer, on the aortic wall and its surrounding PVAT, considering a bi‐directional communication between both layers.