Hybrid bacterial cellulose - pectin films for transdermal delivery of bioactive molecules

CACICEDO, MAXIMILIANO L.; ISLAN, GERMÁN A.; FLORENCIA DRACHEMBERG; VERA A. ALVAREZ; LAURA C. BARTEL; ALEJANDRO D. BOLZÁN ; GUILLERMO CASTRO

Araraquara

Simposio; II International Symposium of Medicinal Chemistry and Regenerative Medicine; 2017

The aim of the present work was to develop a drug delivery platform based on Bacterial cellulose (BC) hybrid membranes containing high methoxylated pectin (HMP). The BC films produced by Komagataeibacter hansenii (ATCC 23769) were modified in-situ by adding different amounts of a HMP to the culture. Characterization of BC-HMP films were performed. Levofloxacin (Levo) and Human Serum albumin (HSA) were used as molecular models to study BC-HMP entrapment and kinetic release.