A Protective Protein Matrix Improves the Discrimination of Nitroxyl from Nitric Oxide by MnIII Protoporphyrinate IX in Aerobic Media

IGNACIO BORON; SEBASTIAN SUAREZ; FABIO DOCTOROVICH; MARCELO MARTI; SARA BARI

JOURNAL OF INORGANIC BIOCHEMISTRY

ELSEVIER SCIENCE INC

Año: 2011

0162-0134

The selectivity of MnIII/II porphyrinates towards nitroxyl or nitric oxide donors provides a convenient starting point for the development of new materials for the speciation of these nitrogen-containing redox relatives. In the present report, we describe the insertion of MnIII protoporphyrinate IX in apomyoglobin and its chemical behavior towards HNO or NO donors, either under anaerobic or aerobic conditions. For comparison and discussion, the MnIII porphyrinate, devoid of the protein matrix, was studied in parallel.